Novel Human-like Influenza A Viruses Circulate in Swine in Mexico and Chile

Discussion Through new surveillance efforts and phylogenetic analysis of IAV-S in Mexico and Chile, we have expanded our understanding of the extensive IAV-S diversity that circulates in swine in Latin America. Most notably, we have identified multiple novel clades of H3N2 and H1N1 viruses of human origin in Mexico and Chile that have not been identified in swine previously, highlighting the importance of the human-swine interface in the evolution of IAV-S diversity in Latin America. The presence of two different IAV-S lineages in Mexico that are related to North American IAV-S (classical H1N1 and H3-cluster IV) also demonstrates the importance of viral migration from US and/or Canadian swine herds into Mexico. The identification of a group of human-origin H3 IAV-S isolates from swine in both Brazil and Chile could be evidence of IAV-S migration between two countries in Latin America, but additional sequence data are needed to rule out the possibility of two independent human-to-swine transmissions in these respective countries. The fact that live swine are not frequently transported between Brazil and Chile supports the likelihood of two independent introductions from humans, but additional data are greatly needed. Consistent with patterns observed globally16, at least 12 introductions of human H1N1pdm09 viruses in to swine were observed in Chile and Mexico since 2009, further contributing to IAV-S diversity. Overall, we identified four key evolutionary processes that genera...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research

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Abstract Chikungunya virus (CHIKV) a re-emerging mosquito-borne alpha virus causes significant distress which is further accentuated in the lack of specific therapeutics or a preventive vaccine, mandating accelerated research for anti-CHIKV therapeutics. In recent years, drug repositioning has gained recognition for the curative interventions for its cost and time efficacy. CHIKV envelope proteins are considered to be the promising targets for drug discovery because of their essential role in viral attachment and entry in the host cells. In the current study, we propose structure-based virtual screening of drug mo...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Conclusion: Our research outcome paves the way to create a device for cough monitoring in real-life situations. Significance: Our proposal is aligned with a more comfortable and less disruptive patient monitoring, with benefits for patients (allows self-monitoring of cough symptoms), practitioners (e.g., assessment of treatments or better clinical understanding of cough patterns), and national health systems (by reducing hospitalizations).
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
DISCUSSION: Contrary to our hypothesis, our evidence suggests Twitter content differs significantly from English mass media content. Evidence from our study helps inform media monitoring and communications surveillance during global public health crises, such as infectious disease outbreaks, as well as reactions to health promotion campaigns. PMID: 31314733 [PubMed - in process]
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
CONCLUSIONS Pneumococcal meningitis is probably underdiagnosed and underreported in S ão Paulo. Differentiated rates of pneumococcal meningitis diagnosis and reporting in each microregion, according to the São Paulo Index of Social Responsibility, might explain our results.
Source: Revista de Saude Publica - Category: International Medicine & Public Health Source Type: research
Conclusion: the results shown indicate that there is no significant relationshi p between such variables. The findings are important at the level of drug policies to support the development of new preventive strategies for drug use.RESUMO Objetivo: determinar a rela ção entre o conhecimento das consequências e o uso de drogas em estudantes de graduação de uma universidade em San José, Costa Rica. Método: este estudo, de corte transversal, examina o perfil demográfico da amostra e a relação entre o conhecimento das consequências, o uso de drogas e o ...
Source: Texto e Contexto - Enfermagem - Category: International Medicine & Public Health Source Type: research
An 80-year-old woman presented to the emergency department with acute behavioural changes. She experienced emotional liability, urinary incontinence, copracrasia, tremors, confusion, slowness of movement and difficulty in problem solving. Her previous m...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Publication date: Available online 17 July 2019Source: Microbiological ResearchAuthor(s): Yiqin Deng, Youlu Su, Songlin Liu, Lei Bei, Zhixun Guo, Huo Li, Chang Chen, Juan FengAbstractVibrio alginolyticus is an opportunistic pathogen that is a threat to the aquaculture industry. Evidence has revealed critical roles for small RNAs (sRNAs) in bacterial physiology and pathology by modulating gene expression post transcription. However, little information about sRNA-mediated regulation in V. alginolyticus is available. We experimentally verified the existence and characterized the function of sRNA srvg17985 in V. alginolyticus ...
Source: Microbiological Research - Category: Infectious Diseases Source Type: research
Overfishing, hunting and land development have pushed more species closer to extinction, according to a new report. The Red List report by the International Union for Conservation of Nature (IUCN) found that 27% of the more than 105,000 species the organization has analyzed are at risk of extinction, a total of 28,338 different species. IUCN also found that no species on its list have shown any sign of improvement since it was last updated in December 2018. “Things are not getting better, they are getting worse,” Craig Hilton-Taylor, head of the IUCN Red List unit, tells TIME. The Red List places the 105,732 s...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Environment onetime World Source Type: news
ConclusionsOur prospective study performed in a real-world setting showed a high immunogenicity and safety of HBV-AS04 vaccine in patients with CKD not yet on maintenance dialysis. Studies provided with longer follow-ups are under way to assess the durability of seroprotection in responders.
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 17 July 2019Source: Annals of Emergency MedicineAuthor(s): Carissa Bunke, Andrew N. Hashikawa, Aditi MitraMany children and adolescents have access to portable electronic devices. Although not always the case, these devices are often charged at nighttime, especially while being used in bed. There are increasing media reports of electric current injury from the portable electronic devices’ charging cables, particularly with equipment that is available for lower cost from generic manufacturers. A 19-year-old woman presented to the pediatric emergency department after a burn from her g...
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
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