Abstract 3483: Synergistic combination therapy with molecular targeted drugs in glioma stem-like cells

Conclusions] Inhibition of RTK and its downstream molecule induced synergistic antitumor effects but sensitivity of GSC lines to therapies was diverse. Examining colonies initiated by GSCs obtained from individual patients may be useful for drug sensitivity testing in personalized cancer therapy.Citation Format: Takashi Shingu, Lindsay Holmes, Verlene Henry, Khatri Latha, Anupama E. Gururaj, Laura A. Gibson, Tiffany Doucette, Frederick F. Lang, Ganesh Rao, Liang Yuan, Erik P. Sulman, Nicholas P. Farrell, Waldemar Priebe, Kenneth R. Hess, Yaoqi A. Wang, Jian Hu, Oliver Bogler. Synergistic combination therapy with molecular targeted drugs in glioma stem-like cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3483. doi:10.1158/1538-7445.AM2015-3483

Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Shingu, T., Holmes, L., Henry, V., Latha, K., Gururaj, A. E., Gibson, L. A., Doucette, T., Lang, F. F., Rao, G., Yuan, L., Sulman, E. P., Farrell, N. P., Priebe, W., Hess, K. R., Wang, Y. A., Hu, J., Bogler, O. Tags: Experimental and Molecular Therapeutics Source Type: research