Abstract 2889: Distinct microbiome in colorectal cancers with the CpG Island Methylator Phenotype

Conclusions: CIMP+ CRC are associated with a distinct microbiome including pks containing bacteria (K. pneumoniae and E. coli) and 2HG producing bacteria (Fusobacterium), raising the possibility that the methylation defect could be contributed to by the microbiome.Citation Format: Ang Sun, Matteo Cesaroni, Christian Jobin, Carlos Barrero, Jaroslav Jelinek, Jacqueline D. Sautter, Thomas E. Rams, Salim Merali, Jean-Pierre Issa. Distinct microbiome in colorectal cancers with the CpG Island Methylator Phenotype. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2889. doi:10.1158/1538-7445.AM2015-2889

Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Sun, A., Cesaroni, M., Jobin, C., Barrero, C., Jelinek, J., Sautter, J. D., Rams, T. E., Merali, S., Issa, J.-P. Tags: Tumor Biology Source Type: research