Abstract 921: Opposing effects of the Hippo-Yap pathway and c-Myc in phenotypic determination of mouse hepatocytic tumors induced by myrAkt

In conclusion, while both the Hippo-Yap pathway and c-Myc enhance hepatocarcinogenesis, the activation of the former induces ductular differentiation in hepatocytic tumors generating a CC-like phenotype, whereas the latter suppresses the transdifferentiation and maintains hepatocytic features.Citation Format: Masahiro Yamamoto, Bing Xin, Xi Chen, Kiyonaga Fujii, Takako Ooshio, Yuji Nishikawa. Opposing effects of the Hippo-Yap pathway and c-Myc in phenotypic determination of mouse hepatocytic tumors induced by myrAkt. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 921. doi:10.1158/1538-7445.AM2015-921

Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Yamamoto, M., Xin, B., Chen, X., Fujii, K., Ooshio, T., Nishikawa, Y. Tags: Carcinogenesis Source Type: research