A serological epidemiology survey of antibodies against four HPV subtypes in Uygur women in Xinjiang.

This study evaluated the distribution of antibodies against four human papillomavirus (HPV) subtypes and their related factors among Uygur women. A cross-sectional study was conducted from March 2006 to May 2007 that included interviews with 883 women aged 17-54 years living in Yutian county. Demographic indicators, disease history, sexual behaviour history and other parameters were included in the questionnaire. A fluorescence detection method was used to detect anti-HPV6, -11, -16, and -18 antibodies in venous blood serum. The positivity rate for any type of antibody (anti-HPV6, -11, -16, and -18) in the study population was 13.4%, and the individual positivity rates were 9.5%, 2.6%, 4.3%, and 0.68%, respectively. Peak positivity rates for the anti-HPV16 antibody were found in women who were 36-40 and 46-50 years old. The seroprevalence of high-risk HPV16 was associated with the number of sexual partners. The rate of infection with high-risk HPV was low amongst Uygur women from rural areas, even though there was a high incidence of cervical cancer. Loyalty to one sexual partner decreased the risk of high-risk HPV infection. This study may provide useful reference data for the prevention and treatment of HPV and cervical cancer and for the application of HPV vaccines. PMID: 26255734 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research