A Cutting-Edge Fertility Technique For Pediatric Cancer Patients

CHICAGO (AP) -- Barely 2 years old, Talia Pisano is getting tough treatment for kidney cancer that spread to her brain. She's also getting a chance at having babies of her own someday.  To battle infertility sometimes caused by cancer treatment, some children's hospitals are trying a futuristic approach: removing and freezing immature ovary and testes tissue, with hopes of being able to put it back when patients reach adulthood and want to start families. No one knows yet if it will work. It has in adults - more than 30 babies have been born to women who had ovarian tissue removed in adulthood, frozen, and put back after treatment for cancer or other serious conditions. In lab animals, it's worked with frozen and thawed testes tissue. But the procedures are still experimental in children who haven't reached puberty, and too new to have been attempted. There are challenges to making immature eggs and sperm from removed tissue suitable for conception. Still, fertility researchers hope to refine the science while the first generation of children whose tissue has been put on ice grows up. Families like Talia's are clinging to that optimism. The dark-eyed toddler who loves princesses and play dough had an ovary removed and frozen in April. She was treated for kidney cancer last year but when it spread, doctors started harsher treatment including brain radiation. "It seemed very new and pretty amazing that we can do something like this and help her in a bigger way," ...
Source: Science - The Huffington Post - Category: Science Source Type: news

Related Links:

Publication date: Available online 19 July 2018Source: Life SciencesAuthor(s): Amr Ahmed El-Arabey, Salama Abdu Salama, Adel Rashad Abd-AllahAbstractIn 2015, more than 1.6 million new cancer cases with 589,430 deaths were estimated over worldwide. Cancer is a complex disease with abnormal cell growth control which is hallmarked by chromosome misalignment and consequently genomic instability. Mitosis is a well-known target for chemotherapy as taxol and colchicines inhibit tumor cell division by inhibiting mitotic spindle plasticity. Accumulating evidence has revealed that the Centromere-associated protein E (CENP-E) is expr...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 July 2018Source: Life SciencesAuthor(s): Mohammad Rasheduzzaman, Jae-Kyo Jeong, Sang-Youel ParkAbstractAimsTRAIL is a promising anticancer agent that has the potential to sensitize a wide variety of cancer or transformed cells by inducing apoptosis. However, resistance to TRAIL is a growing concern. Current manuscript aimed to employing combination treatment to investigate resveratrol induced TRAIL sensitization in NSCLC.MethodA549 and HCC-15 cells were used in experimental design. Cell viability was determined by morphological image, crystal violet staining and MTT assay. Apoptosis wa...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 July 2018Source: Life SciencesAuthor(s): Yawei Shi, Yang Zhao, Yunjian Zhang, NiJiati AiErken, Nan Shao, Runyi Ye, Ying Lin, Shenming WangAbstractAimsBreast cancer is the major diagnosed cancer and the leading reason of cancer related death among women, and the tumor size is one of the risk factors. Therefore, it is significant to reveal the principle of breaking the subtle homeostasis of cell cycle and sustaining chronic proliferation of cancer cells.Main methodsThe expression of TNNT1 was examined by qPCR and western blotting. The effect of TNNT1 on cell proliferation was detected by...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: September 2018Source: Biomedical Signal Processing and Control, Volume 46Author(s): Supriya Patil, Gourish Naik, Radhakrishna Pai, Rajendra GadAbstractInvention of the microarray technology has rendered it possible to inspect the whole genome at once in cancer classification. However, in order to curtail the computational complexity and augment the accuracy of cancer classification, it is essential to sift the vast microarray data for the informative genes. In this paper, Thresholding and Ratio methods are presented, individually as well as conjointly (hybrid method) to choose optimal gene subset from the...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
We present a quantitative study of the performance of two automatic methods for the early detection of ovarian cancer that can exploit longitudinal measurements of multiple biomarkers. The study is carried out for a subset of the data collected in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). We use statistical analysis techniques, such as the area under the Receiver Operating Characteristic (ROC) curve, for evaluating the performance of two techniques that aim at the classification of subjects as either healthy or suffering from the disease using time-series of multiple biomarkers as inputs. The first ...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Publication date: Available online 19 July 2018Source: Plant Physiology and BiochemistryAuthor(s): Mohammad Javad Ahmadi Lahijani, Mohammad Kafi, Ahmad Nezami, Jafar Nabati, Mohammad Zare Mehrjerdi, Shirin Shahkoomahally, John ErwinAbstractRising atmospheric CO2 concentrations are expected to impact the productivity of plants. Cultivars demonstrate different responses to CO2 levels, hence, screening and recognizing the cultivars with a higher capacity for translocation of photoassimilates would certainly be beneficiary. To investigate the interactive impact of enhancing CO2 on physiology, cellular fine structure and photoa...
Source: Plant Physiology and Biochemistry - Category: Biochemistry Source Type: research
Publication date: Available online 18 July 2018Source: PeptidesAuthor(s): Sevil Arabaci Tamer, Alper Yildirim, M. Kutay köroğlu, Özge Çevik, Feriha Ercan, Berrak Ç. YeğenAbstractTesticular torsion causes ischemia-reperfusion injury and an increased risk of infertility. Nesfatin-1 is a novel peptide with antioxidant, anti-inflammatory and anti-apoptotic properties. In the present study, we aimed to investigate the putative beneficial effects of nesfatin-1 on oxidative injury and impaired testicular function induced by testis torsion. Under anesthesia, male Sprague-Dawley rats (180-230 g; n = ...
Source: Peptides - Category: Biochemistry Source Type: research
In conclusion, these results suggest the potential preventive effects of the five phytochemicals on the promoting effect of Ni on human lung cancer cell invasion. In addition, the preventive effects are associated with downregulation of the TLR4/NF-κB signaling pathway, especially for quercetin and chrysin.
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: 10 November 2018Source: Sensors and Actuators B: Chemical, Volume 273Author(s): Shuangshuang Wu, Changhui Chen, Haitang Yang, Wei Wei, Min Wei, Yuanjian Zhang, Songqin LiuAbstractPoly(ADP-ribose) polymerase-1 (PARP-1) monitoring has attracted extensive attention because it serves a vital role in human pathologies. However, only a few researches about its detection methods have been reported because PARP-1 and its catalyzed product poly(ADP-ribose) polymer (PAR) are lack of optical or electrochemical activity. Herein, a convenient fluorescence “turn-off-on” nanosensor based on cationic conjugat...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
In this study, a fluorescent sensing strategy has been developed for rapid and ultrasensitive detection of BCR-ABL1 mRNA in chronic myeloid leukemia (CML) based on DNAzyme Cleavage-induced Rolling circle amplification (DCR for short). In the presence of BCR-ABL1 mRNA, DNAzyme was activated to split the target sequence into two fragments, producing the 3′ terminus on the forward cleavage fragments. After T4 polynucleotide kinase (PNK) modification reaction, the forward cleavage fragments were extended by rolling circle amplification (RCA). Plenty of long single DNA strands were produced and partially hybridized with t...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
More News: Anemia | Babies | Boys | Brain | Brain Cancers | Brain Tumor | Cancer | Cancer & Oncology | Chemotherapy | Children | Girls | Hospitals | Infertility | Kidney Cancer | Kidney Transplant | Kidney Transplantation | Learning | Leukemia | Medical Ethics | Neurology | Ovarian Cancer | Ovaries | Pediatrics | Pregnancy | Reproduction Medicine | Science | Sickle Cell Anemia | Stem Cell Therapy | Stem Cells | Transplant Surgery | Transplants | Universities & Medical Training | Urology & Nephrology | Websites | Women