Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats

Conclusions:
The results indicate that vildagliptin reduces T2DM-induced increase in post-MI acute mortality possibly by restoring the autophagic response through attenuation of Bcl-2-Beclin-1 interaction.

Source: Cardiovascular Diabetology - August 11, 2015 Category: Cardiology Authors: Hiromichi MuraseAtsushi KunoTakayuki MikiMasaya TannoToshiyuki YanoHidemichi KouzuSatoko IshikawaToshiyuki TobisawaMakoto OgasawaraKeitaro NishizawaTetsuji Miura Source Type: research