Indian boy with giant hands from local gigantism gets life changing operation

Mohammad Kaleem, eight, from Jharkhand State, eastern India, was born with a form of giantism which has seen his hands and arms grow until they weighed a colossal two stone between them.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Condition:   Acromegaly Due to Pituitary Adenoma Interventions:   Other: GIP-A;   Other: Placebo Sponsors:   University of Copenhagen;   Rigshospitalet, Denmark;   Aarhus University Hospital;   Aalborg Universitetshospital;   Odense University Hospital;   Herlev and Gentofte Hospital Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Goltzman D Abstract Primary hyperparathyroidism is among the most common causes of hypercalcemia. However, ingestion of medication, including hydrochlorathiazide, lithium, and foscarnet, excessive vitamin A ingestion, endocrinopathies such as hyperthyroidism, adrenal insufficiency, and acromegaly, abnormal nutrient intake such as parenteral nutrition in preterm infants and milk-alkali syndrome, and prolonged immobilization have all been associated with hypercalcemia. The most common cause of nonparathyroid hypercalcemia is neoplasia. Hypercalcemia is generally due to the secretion of parathyroid hormone (P...
Source: Frontiers of Hormone Research - Category: Endocrinology Tags: Front Horm Res Source Type: research
Conclusions:MEN1 alterations can be of significance in FIPA patients and screening could be offered toAIP mutation-negative patients without MEN1 features. Further studies are needed to clarify the role ofMEN1 in FIPA patients.Pathobiology
Source: Pathobiology - Category: Pathology Source Type: research
Publication date: 2019Source: Advances in Virus Research, Volume 103Author(s): Eugene V. Koonin, Natalya YutinAbstractThe Nucleocytoplasmic Large DNA Viruses (NCLDV) of eukaryotes (proposed order “Megavirales”) comprise an expansive group of eukaryotic viruses that consists of the families Poxviridae, Asfarviridae, Iridoviridae, Ascoviridae, Phycodnaviridae, Marseilleviridae, Pithoviridae, and Mimiviridae, as well as Pandoraviruses, Molliviruses, and Faustoviruses that so far remain unaccounted by the official virus taxonomy. All these viruses have double-stranded DNA genomes that range in size from about 100 k...
Source: Advances in Virus Research - Category: Virology Source Type: research
ConclusionAll five ACRODAT ® parameters had some influence on disease activity from the patients’ perspective. To account for patients’ preferences and optimize treatment and outcomes, a holistic disease management approach should be employed.
Source: Pituitary - Category: Endocrinology Source Type: research
ConclusionThis study described the profiles of acromegaly in Taiwan. It is important to enhance early diagnosis and timely commencement of treatment to prevent serious complications of acromegaly.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
We report an unusual plurihormonal tumor co-expressing Pit-1 and SF-1 along with hormones made by cells of both lineages. Its simultaneous occurrence adjacent to a corticotroph tumor raises questions regarding the pathogenesis of these tumors. We pr opose the possibility of a stem cell tumor with multiple lineage differentiation. We hypothesize that pregnancy might have played a permissive role in tumorigenesis.
Source: Endocrine Pathology - Category: Pathology Source Type: research
Publication date: March–April 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 13, Issue 2Author(s): Leila Moradi, Fatemeh Amiri, Hajieh ShahbazianAbstractPatients with acromegaly have soft tissue overgrowth that induced characteristic clinical presentation. A growth hormone-secreting adenoma of the anterior pituitary gland is the most common cause of acromegaly. Metabolic and somatic features of acromegaly caused by high serum concentrations of insulin-like growth factor-I (IGF-I) and excess growth hormone (GH) production. we present a case of ‘pseudoacromegaly’ with a...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Condition:   Acromegaly Interventions:   Drug: CRN00808;   Drug: Placebo Sponsor:   Crinetics Pharmaceuticals Inc. Recruiting
Source: - Category: Research Source Type: clinical trials
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