Laboratory coagulation tests in patients treated by direct oral anticoagulants (DOACs).

[Laboratory coagulation tests in patients treated by direct oral anticoagulants (DOACs)]. Presse Med. 2015 Aug 3; Authors: Sié P Abstract Routine clotting time assays (Prothrombin Time/INR, activated Partial Thromboplastin Time [aPTT]) are prolonged at variable extent by direct oral anticoagulants (DOAC), according to the assay, the reagent and the type of DOAC. These assays are not reliable for monitoring the intensity of treatment and the measurement of the plasma level of the DOAC is usually not required. At high concentrations, DOAC interfere with the routine clotting assays, making them difficult to interpret. In critical situations such as major bleeding or urgent invasive procedure, the measurement of DOAC level and its kinetics are simple and useful to manage the patient. PMID: 26248706 [PubMed - as supplied by publisher]
Source: Presse Medicale - Category: Journals (General) Authors: Tags: Presse Med Source Type: research

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Source: The American Journal of Surgery - Category: Surgery Source Type: research
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Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
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Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
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Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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