Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations

This study evaluated the role of humoral activity in IBS-D. Methods A single mucosal jejunal biopsy, luminal content and blood were obtained from healthy volunteers (H; n=30) and IBS-D (n=49; Rome III criteria) participants. Intraepithelial lymphocytes, mast cells, B lymphocytes and plasma cells were studied by imaging techniques. Differential gene expression and pathway analysis were assessed by microarray and PCR techniques. Blood and luminal immunoglobulins (Igs) were quantified. Gastrointestinal symptoms, respiratory atopy and stress and depression were also recorded. Results Patients with IBS-D showed a higher number and activation of mucosal B lymphocytes and plasma cells (p
Source: Gut - Category: Gastroenterology Authors: Tags: Irritable bowel syndrome Neurogastroenterology Source Type: research

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Contributors : Alexander B Niculescu ; Helen Le-NiculescuSeries Type : Expression profiling by arrayOrganism : Homo sapiensShort-memory dysfunction is a key early feature of Alzheimer Disease. Psychiatric patients may be at higher risk for memory dysfunction and subsequent Alzheimer due to the negative effects of stress and depression on the brain. We carried out longitudinal within-subject studies in male and female psychiatric patients to identify blood gene expression biomarkers that track short term memory as measured by the retention measure in the Hopkins Verbal Learning Test. These biomarkers were prioritized with a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Publication date: Available online 31 March 2020Source: Life SciencesAuthor(s): Mohsen Enayati, Belal Mosaferi, Judith R. Homberg, Danielle Mendes Diniz, Ali-Akbar Salari
Source: Life Sciences - Category: Biology Source Type: research
Donors of death due to anoxic brain injury such as suicidal hanging are at risk for a severe catecholamine surge leading to an acute myocardial stress that can cause global tissue hypoxia as well as pulmonary edema and barotrauma, all of which may potentially adversely impact myocardial tissue. Concerns have been raised about potential higher rates of Primary Graft Dysfunction (PGD) in heart transplant recipients of such donors due to this acute myocardial stressor. We wanted to assess if this mechanism of donor death does carry an increased risk of PGD or other adverse outcomes in our single center experience.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (739) Source Type: research
Cognitive impairment and mood deviation often occurs in patients with heart failure. Frailty and sarcopenia have been widely studied in patients with heart disease, but cognitive frailty has been little explored. High complexity of patients referred for heart transplantation connected with socioeconomic characteristics in a developing country underlines the importance to investigate cognitive and mood conditions in this population. The aim of the study is to evaluate the prevalence of cognitive impairment and depression symptoms in patients with heart failure in waiting list for heart transplantation (HTx).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (571) Source Type: research
Burnout is common in all types of physicians, but little is known about burnout in lung transplant physicians. The purpose of this study was to explore burnout and its relationship to job factors and depression in lung transplant physicians.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (389) Source Type: research
Prior studies suggest an association between elevated depressive symptoms following lung transplant (LT) and mortality. We sought to test this association using a longitudinal cohort with 3-years of follow up, and to determine the long-term impact of LT on depressive symptoms.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (282) Source Type: research
Health literacy is an established concept in the health care world that seeks to understand people's comprehension of various healthcare information and their ability to apply it. Health literacy has been extensively studied in the heart failure literature, and inadequate health literacy has been linked to impaired ability to assess risk versus benefit information, poorer physical and mental health, increased hospitalizations, and an inability to fully engage in treatment planning and self-care.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (74) Source Type: research
It’s widely recognised that emotions can directly affect stomach functionality. As early as 1915, influential physiologist Walt Cannon noted that stomach functions are changed in animals when frightened. The same is true for humans. Those who stress a lot often survey diarrhoea or stomach pain. Related Posts:Can changes in the brain affect your microbiome?Researchers want to know how newest IBS medication helps…Stomach disorders involve both brain-to-gut plus…So Why Am I Writing About IBS?Brand new study finds link between depressive disorder and…The post The brain and the gut talk to each other&...
Source: My Irritable Bowel Syndrome Story - Category: Gastroenterology Authors: Tags: IBS News Source Type: blogs
ConclusionsThis model‐based subgrouping of IBS partly supports the distinction of subgroups based on bowel habits, but additionally distinguishes subgroups with or without co‐morbid extraintestinal somatic and psychological symptoms. The resulting groups show specific profiles of symptom combinations.
Source: Alimentary Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSION: IBS patients had a more than three times greater risk of TMD compared to HC. The risk of having TMD was similar in different IBS subtypes. IBS patients that also fulfilled criteria for TMD seem to share along with chronic facial and abdominal pain a significant co-occurrence with psychiatric disorders and female preponderance. PMID: 28104985 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
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