Nimodipine in otolaryngology: from past evidence to clinical perspectives.
Nimodipine in otolaryngology: from past evidence to clinical perspectives. Acta Otorhinolaryngol Ital. 2015 Jun;35(3):135-45 Authors: Monzani D, Genovese E, Pini LA, DI Berardino F, Alicandri Ciufelli M, Galeazzi GM, Presutti L Abstract As L-type voltage-gated calcium channels (VGCCs) control Ca(2+) influx and depolarisation of cardiac and vascular smooth muscle, they represent a specific therapeutic target for calcium channel blockers (CCBs), which are approved and widely used to treat hypertension, myocardial ischaemia and arrhythmias. L-type currents also play a role in calcium entry in the sensory cells of the inner ear. In hair cells of both cochlea and labyrinth, calcium cytoplasmic influx is the first physiological process that activates complex intracellular enzymatic reactions resulting in neurotransmitter release. Excessive calcium ion entry into sensory cells, as a consequence of L-VGCCs malfunction is responsible for over-activation of phospholipase A2 and C, protein kinase II and C, nitric oxide synthase and both endonucleases and depolymerases, which can cause membrane damage and cellular death if the cytoplasmic buffering capacity is overcome. Nimodipine, a highly lipophilic 1-4 dihydropyridine that easily crosses the brain-blood barrier, is generally used to reduce the severity of neurological deficits resulting from vasospasm in patients with subarachnoid haemorrhage. Moreover, due to its selective blocking activity on L-channel calcium c...
CONCLUSION: TAVR with a balloon-expandable system is safe and effective and can be used for patients with severe AS in China. It requires careful patient selection and preoperative assessment so as to reduce the 30-day postoperative mortality rate. PMID: 29236149 [PubMed - as supplied by publisher]
Authors: Schlitt A, Guha M, Noutsias M, Klein HH, Klein HU Abstract Assessment of a permanent risk of life-threatening ventricular arrhythmia in patients with severely reduced left ventricular ejection fraction (LVEF
New J. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7NJ04266C, PaperMariana Lozano Gonzalez, Maria Teresa Ramirez-Apan, Antonio Nieto-Camacho, Ruben Alfredo Toscano, Cecilio Alvarez Toledano A novel series of (Z)-2-(hydroxy(aryl)methylene)-2,3-dihydro-1H-indanone derivatives were designed, synthesized and evaluated as cytotoxic agents against six cancer cell lines. In vitro studies showed that most of the molecules exhibited significant... The content of this RSS Feed (c) The Royal Society of Chemistry
CONCLUSION: The latter process may be induced by transient auditory events in normal processing but it persists in tinnitus, driven by phantom signals from the auditory pathway. Several tinnitus therapies attempt to suppress tinnitus through plasticity, but repeated sessions will likely be needed to prevent tinnitus activity from returning owing to deafferentation as its initiating condition. PMID: 29234817 [PubMed - as supplied by publisher]
We report pulmonary resections for lung cancers in 2 patients with partial anomalous pulmonary venous connection (PAPVC) identified preoperatively. In case 1, right upper lobectomy was performed as the definitive operation for both lung cancer and PAPVC in the same lobe. In case 2, because lung cancer and PAPVC existed in different lobes, cardiac catheterization was performed to evaluate the need for correction of the PAPVC. Then, left lower lobectomy was safely performed without correcting the PAPVC located in the left upper lobe. The treatment plan for patients with PAPVC who require pulmonary resection should be careful...
PMID: 29233347 [PubMed - in process]
ConclusionsOur studies provide strong rationale for the near‐term development of specific HDAC3 inhibitors for the treatment of CRPC.
Unfortunately some children have to spend Christmas in hospital and to make the day a little bit brighter seven-year-old Aroha White, is making stockings for children on her cancer ward in Perth.
Hyo-Jung Kim, Ji-Soo Kim
Pioneering psychiatrist in learning disability. She was born in Isleworth, UK, on April 10, 1939, and died of cancer in Stalbridge, UK, on June 12, 2017, aged 78 years.
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