Phosphorylated epidermal growth factor receptor expression and KRAS mutation status in salivary gland carcinomas

Conclusion Salivary gland carcinomas show a high expression of pEGFR. This high expression correlates with lymph node metastasis, which supports the hypothesis that a high pEGFR expression facilitates lymphogenous metastasis. Due to this pEGFR expression, status may be a negative predictive factor in salivary gland carcinoma diagnostics. Patients with pN-positive salivary gland cancer may benefit from EGFR-inhibiting drugs. Clinical relevance The EGFR pathway may be a potential target for chemotherapy of advanced unresectable salivary gland carcinomas.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research