Non–immunoglobulin A mesangial immune complex glomerulonephritis in kidney transplants

We have observed a predominantly mesangial non–immunoglobulin A immune complex mesangial glomerulopathy (MG) in renal transplants with mesangial deposits by immunofluorescence and electron microscopy. Clinicopathological features of 28 patients with MG were analyzed and compared with 28 transplant controls, matched for age, sex, ethnicity, donor type, estimated glomerular filtration rate, and interval from transplant to biopsy. Indications for biopsy in the MG group were allograft dysfunction in 64%, allograft dysfunction/proteinuria in 29%, and proteinuria in 7%.

Source: Human Pathology - June 25, 2015 Category: Pathology Authors: Giovanna A. Giannico, Shanna Arnold, Anthony Langone, Heidi Schaefer, J. Harold Helderman, David Shaffer, Agnes B. Fogo Tags: Original contribution Source Type: research