Abnormal fast fluctuations of electrocochleography and otoacoustic emissions in Menière's disease.

Abnormal fast fluctuations of electrocochleography and otoacoustic emissions in Menière's disease. Hear Res. 2015 Jul 29; Authors: Gerenton G, Giraudet F, Djennaoui I, Pavier Y, Gilain L, Mom T, Avan P Abstract The responses of cochlear hair cells to sound stimuli depend on the resting position of their stereocilia bundles, which is sensitive to the chemical and mechanical environment. Cochlear hydrops, a hallmark of Menière's disease (MD), which is likely to come with disruption of this environment, results in hearing symptoms and electrophysiological signs, such as excessive changes in the cochlear summating potential (SP) and in the postural shifts of distortion-product otoacoustic emissions (DPOAEs). Here, SP from the basal part of the cochlea and DPOAEs from the apical part of the cochlea were recorded concomitantly in 73 patients with a definite MD, near an attack (n = 40) or between attacks with no clinical symptoms (n = 33), to compare their sensitivities to posture and evaluate their stability. The phase of the 2f1-f2 DPOAEs was monitored during body tilt, with stimuli f1 = 1 kHz and f2 = 1.2 kHz at 72 dB SPL. Extratympanic electrocochleography was performed in response to 95-dBnHL clicks. The normal limits of the DPOAE phase shift with body tilt, [-18°, +38°], and of the SP to action-potential (AP) ratio, < 0.40, were exceeded in 75% and 60% of patients, respectively, near an attack. In these patients, but not in the...
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research