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Could statins be used to fight a deadly viral infection?

(University of Pennsylvania School of Medicine) Two Perelman School of Medicine microbiologists may have found a way to use statins, the well-known blockbuster cholesterol-lowering drugs, to fight the hantavirus, a mysterious and lethal microorganism that appeared suddenly in the US southwest over 20 years ago.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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(Reuters Health) - Compared to inactive people, recreational soccer players have lower cholesterol, blood pressure and resting heart rates as well as less fat mass, a research review suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Authors: Farkas GJ, Gorgey AS, Dolbow DR, Berg AS, Gater DR Abstract OBJECTIVE: We aimed to examine the influence of sex on the distribution of adipose tissue, as well as proinflammatory adipokine and cardiometabolic profiles, in chronic motor complete spinal cord injury (SCI). DESIGN: Cross-sectional and correlational study. SETTING: Academic rehabilitation hospital. PARTICIPANTS: Forty-seven individuals with chronic motor complete SCI classified according to sex (males: age 44.0 ± 10.9 y, body mass index (BMI) 27.2 ± 5.8, level of injury (LOI) C4 - L1; females...
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
This recipe is rich with goodness and flavor — and is comfort food at its best. The ingredients are simple: Quality grass-fed beef is married together with vegetables and a few glasses of full-bodied red wine. I’ve used carrot puree to thicken the Bourguignon sauce towards the end of cooking, which is a lovely way of thickening sauces without using refined white flours. Don’t overcook your cauliflower. Make sure to chop the ingredients finely before cooking and keep an eye on the cooking time. Blend it when hot, which will result in a creamy, white mash that tastes wonderful. This recipe is from my cookbo...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cooking diet Food healthytime weekend recipe Source Type: news
Authors: Wang JM, Ye SD, Li SM, Hu W Abstract OBJECTIVE: To investigate the correlation between 25-hydroxyvitamin D [25(OH)D] and the lipid profile, inflammatory cytokines, and endothelial function in diabetic patients. PATIENTS AND METHODS: A total of 77 patients with type 2 diabetes mellitus treated in our hospital from January 2015 to March 2017 and 73 healthy volunteers were selected. The 25(OH)D, lipids, inflammatory factors, and endothelial function were compared between the two groups. The levels of 25(OH)D in diabetic patients were also compared to detect the levels of serum lipids and inflammatory cyto...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Introduction: In 2030 diabetes will cause one amputation every 20 seconds. Currently 10 to 20% of all diabetic patients develop infected foot ulcers that recur 40% of the time within one year, even when adequately treated by antibiotics, angioplasty or bypass. Therefore, factors other than infection and peripheral artery disease must be incriminated in wound healing in diabetic patients. The identification of those factors is the subject of our study.Methodology: A retrospective study done at CHU-NDS (Centre Hospitalier Notre Dame De Secours) included all patients with infected diabetic ulcers between 2012 and 2017. Age wa...
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
Conclusions: CCTA has incremental prognostic value in all AUC categories, even when the reason for the study was deemed “inappropriate.” This suggests that CCTA may still have clinical value in “inappropriate” indications and that further quality assurance AUC studies are needed.
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Original Articles Source Type: research
Publication date: May 2018 Source:Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1860, Issue 5 Author(s): Andrej Kováčik, Alexander Vogel, Juliane Adler, Petra Pullmannová, Kateřina Vávrová, Daniel Huster In this work, we studied model stratum corneum lipid mixtures composed of the hydroxylated skin ceramides N-lignoceroyl 6-hydroxysphingosine (Cer[NH]) and α-hydroxylignoceroyl phytosphingosine (Cer[AP]). Two model skin lipid mixtures of the composition Cer[NH] or Cer[AP], N-lignoceroyl sphingosine (Cer[NS]), lignoceric acid (C24:0) and cholesterol in a 0.5:0.5:1:1 molar rat...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Publication date: May 2018 Source:Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1860, Issue 5 Author(s): Bárbara Gomes, Sónia Gonçalves, Anibal Disalvo, Axel Hollmann, Nuno C. Santos Recently, it was demonstrated that 25-hydroxycholesterol (25HC), an oxidized cholesterol derivative, inhibits human immunodeficiency virus type 1 (HIV) entry into its target cells. However, the mechanisms involved in this action have not yet been established. The aim of this work was to study the effects of 25HC in biomembrane model systems and at the level of HIV fusion peptide (HIV-FP). Integration of diffe...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
The aim of this study was to evaluate the hypolipidemic effect and mechanisms of total phenylpropanoid glycosides extracted from Ligustrum robustum (Roxb.) Blume (LRTPG) in hamsters fed a high‐fat diet and to discover bioactive components in HepG2 cell model induced by oleic acid. LRTPG of high (1.2 g/kg), medium (0.6 g/kg), and low (0.3 g/kg) doses was administrated daily for 21 consecutive days in hamsters. We found that in hamsters fed a high‐fat diet, LRTPG effectively reduced the concentrations of plasma triglycerides (TG), free fatty acid, total cholesterol, low‐density lipoprotein cholesterol, a...
Source: Phytotherapy Research - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
AbstractIntracellular β-amyloid (Aβ) accumulation is an early event in Alzheimer’s disease (AD) progression. Recently, it has been uncovered that presenilins (PSs), the key components of the amyloid precursor protein (APP) processing and the β-amyloid producing γ-secretase complex, are highly enriched in a special sub-compartment of the endoplasmic reticulum (ER) functionally connected to mitochondria, called mitochondria-associated ER membrane (MAM). A current hypothesis of pathogenesis of Alzheimer’s diseases (AD) suggests that MAM is involved in the initial phase of AD. Since MAM supplie...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
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