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Could statins be used to fight a deadly viral infection?

(University of Pennsylvania School of Medicine) Two Perelman School of Medicine microbiologists may have found a way to use statins, the well-known blockbuster cholesterol-lowering drugs, to fight the hantavirus, a mysterious and lethal microorganism that appeared suddenly in the US southwest over 20 years ago.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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We examined aminonucleoside nephrosis in rats with wild type and inactivated TRPC6.TRPC6 channels were inactivated by CRISPR/Cas9 editing of theTrpc6 gene.TRPC6 inactivation reduced albuminuria in the chronic but not the acute phase.TRPC6 inactivation reduced glomerulosclerosis and ultrastructural changes.TRPC6 inactivation also reduced interstitial changes and renal fibrosis.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research
ConclusionsRhabdomyolysis is a rare but serious complication due to lipid-lowering therapy with statins and fibrates. Treating physicians should be aware and patients should be warned to report about muscle symptoms after starting statins or fibrates. Rhabdomyolysis may occur with mild symptoms and signs and may occur later, even after discontinuation of the drug.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: July 2018 Source:Redox Biology, Volume 17 Author(s): Gessica Serra, Alessandra Incani, Gabriele Serreli, Laura Porru, M.Paola Melis, Carlo I.G. Tuberoso, Daniela Rossin, Fiorella Biasi, Monica Deiana Dietary habits may strongly influence intestinal homeostasis. Oxysterols, the oxidized products of cholesterol present in cholesterol-containing foodstuffs, have been shown to exert pro-oxidant and pro-inflammatory effects, altering intestinal epithelial layer and thus contributing to the pathogenesis of human inflammatory bowel diseases and colon cancer. Extra virgin olive oil polyphenols possess antioxidan...
Source: Redox Biology - Category: Biology Source Type: research
ConclusionsThis comprehensive assessment of risk factors can help support clinicians in reducing the incidence of SIM in their patient population on statins.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
The TV star, from Reading, walks three miles a day, watches what he eats and still enjoys sex. He's also taken statins and a blood-thinner since suffering a stroke in 2014.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract Background: Lipid accumulation product (LAP), a simple and low-cost tool, is a novel biomarker of central lipid accumulation and represents a potential surrogate marker for atherogenic lipoprotein profile. However, its association with lipoprotein subfractions has not been described in the literature. Objective: To determine whether LAP index could be used as a marker of low- and high-density lipoprotein (LDL and HDL) size in Brazilian individuals. Methods: This cross-sectional study included patients (n = 351) of both sexes and age between 30-74 years. Clinical and sociodemographic data and family history of dise...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Abstract Background: Unstable angina (UA) is a common cause of hospital admission; risk stratification helps determine strategies for treatment. Objective: To determine the applicability of two-dimensional longitudinal strain (SL2D) for the identification of myocardial ischemia in patients with UA. Methods: Cross-sectional, descriptive, observational study lasting 60 days. The sample consisted of 78 patients, of which fifteen (19.2%) were eligible for longitudinal strain analysis. The value of p
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Abstract Background: Unstable angina (UA) is a common cause of hospital admission; risk stratification helps determine strategies for treatment. Objective: To determine the applicability of two-dimensional longitudinal strain (SL2D) for the identification of myocardial ischemia in patients with UA. Methods: Cross-sectional, descriptive, observational study lasting 60 days. The sample consisted of 78 patients, of which fifteen (19.2%) were eligible for longitudinal strain analysis. The value of p
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Eggs have been a taboo food for decades, since they are high in cholesterol, but the latest science suggests that they might not be as unhealthy as once thought. In a study published in the journal Heart, researchers from China found that people who ate an average of one egg per day had lower rates of heart disease and an even lower risk of having a bleeding stroke than people who did not eat eggs. The study included nearly half a million people in China who filled out questionnaires about their egg-eating habits and were followed for nine years on average for heart-related health events. People who said they ate eggs da...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition healthytime Source Type: news
ABSTRACT Objective The goal of this study were to investigate the effects of continuous exercise with/or without the ingestion the Camu-camu pulp in a rat model of obesity. Methods Neonate male Wistar rats, receiving monosodium glutamate, subcutaneously were separated into foour groups: sedentary group S (no treatment), exercise group E (continuous swimming training), Camu-camu group C (25mL of pulp of Camu-camu/day) and exercise and Camu-camu group EC (25mL of pulp of Camu-camu/day, continuous swimming). After 12 weeks, the animals were received euthanasia. Results The exercise program was conducted for five days for 12 w...
Source: Revista de Nutricao - Category: Nutrition Source Type: research
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