Smad7 inhibits Ang II-mediated hypertensive nephropathy in a mouse model of hypertension

In conclusion, Smad7 may be a therapeutic agent for Ang II-mediated hypertensive nephropathy. Inhibition of the Sp1/Smad3/NF-kB/miR-29b regulatory network may be a mechanism by which Smad7 inhibits hypertensive nephropathy.

Source: Clinical Science - February 11, 2014 Category: Biomedical Science Authors: G Liu, Y Li, X R. Huang, L Wei, Y Zhang, M Feng, X Meng, H Chen, Y Shi, H Y. Lan Source Type: research