Clinical Trial of Pulmonary Cryptococcosis in China

Condition:   CryptococcosisIntervention:   Sponsors:   Zhixin Liang;   Chinese PLA General Hospital;   Beijing Chao Yang Hospital;   Ministry of Health, China;   Peking University Third Hospital;   Tianjin Medical University General Hospital;   First Hospital of China Medical University;   Shengjing Hospital;   Second Hospital of Jilin University;   Shandong Provincial Hospital;   Shanghai Huadong Hospital;   Nanjing PLA General Hospital;   Fuzhou General Hospital;   Guangzhou Institute of Respiratory Disease;   Wuhan TongJi Hospital;   Xi’an Jiaotong University College of Medicine;   Guizhou Provincial People's Hospital;   Shenyang Military General Hospital;   Second Hospital of Hebei Medical University;   Xiangya Hospital of Central South University;   Fujian Provincial Hospital;   Fujian Fuzhou Pulmonary Hospital;   Southwest Hospital, China;   First Affiliated Hospital of Zhejiang University;   Wenzhou Medical University;   Shanghai Zhongshan&nbs...
Source: - Category: Research Source Type: clinical trials

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PMID: 32459503 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization.
Source: Annals of Clinical Microbiology and Antimicrobials - Category: Microbiology Authors: Tags: Case report Source Type: research
Publication date: Available online 19 May 2020Source: Medical Mycology Case ReportsAuthor(s): Angel Almendros, Daniela H. Muguiro, Fraser I. Hill, Vanessa R. Barrs
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
ABSTRACT Cryptococcosis is caused by yeasts of the Cryptococcus neoformans/C. gattii complex, presenting cutaneous, respiratory and disseminated forms. A 44-year-old immunocompetent male with facial lesion and latent pneumonia was hospitalized and misdiagnosed with paracoccidioidomycosis. Computerized tomography scans showed pulmonary and neurological involvement, and cultures/China ink, cryptococcal antigen test and restriction fragment length polymorphism of urease gene (URA5-RFLP) confirmed C. neoformans genotype VNI. Hemoculture indicated ampicillin-resistant Klebsiella pneumoniae (healthcare-associated infection). Flu...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
This study aimed to investigate the interaction of MINO and FLU against FLU-resistant C. neoformans both in vitro and in vivo. We found that the combination of MINO and FLU had a synergistic effect on FLU-resistant C. neoformans in vitro. For all FLU-resistant strains, the minimum inhibitory concentration (MIC) of FLU decreased significantly when used in combination with MINO, dropping from>128 μg/ml down to 4–8 μg/ml. Additionally, MINO and FLU had a synergistic effect on both susceptible and resistant C. neoformans biofilms, in which the MIC of FLU decreased from>256 μg/ml down to 4–16 μg/ml...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Pulmonary cryptococcosis is an uncommon infectious disease that can develop in both immunocompromised and immunocompetent patients. The severity of chronic kidney disease (CKD) was reported to be one of the ri...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research
We report a case of systemic cryptococcal infection in an immunosenescent, HIV-negative patient. PMID: 32334491 [PubMed - as supplied by publisher]
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
Abstract Clinical worsening or new manifestation of cryptococcal disease following initiation of anti-retroviral therapy (ART) in an HIV patient is a hallmark of cryptococcal immune reconstitution inflammatory syndrome (C-IRIS). However, it can be difficult to distinguish IRIS from worsening or new infection. Here, we present a case of severe C-IRIS involving multiple cerebellar, spinal, and intradural abscesses and spinal arachnoiditis 7 months after ART initiation in an AIDS patient with uncertain prior ART compliance. He had multiple prior episodes of cryptococcal meningitis with complications necessitating ven...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Background: The prevalence of different underlying cryptococcal diseases in human immunodeficiency virus (HIV)-infected patients screened positive for cryptococcal antigenemia and the association between cryptococcal diseases and serum cryptococcal antigen (CrAg) titers were understudied.Methods: HIV-infected patients with CD4
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
68Ga-pentixafor PET/CT in a 66-year-old woman with newly diagnosed multiple myeloma showed extensive disease in bone and bone marrow. After 6 cycles of chemotherapy, the patient was in complete remission but complained of fever and coughing. Follow-up 68Ga-pentixafor PET/CT showed significantly reduced uptake in bone and bone marrow, consistent with her clinical outcome of myeloma. However, patches, nodules, and ground-grass opacities in bilateral lungs with moderate to intense uptake of 68Ga-pentixafor were noted. The histopathology of the biopsy for the pulmonary nodule confirmed pulmonary cryptococcosis.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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