Gold-diamond nanodevice for hyperlocalized cancer therapy
Precise targeting biological molecules, such as cancer cells, for treatment is a challenge, due to their sheer size. Now, scientists have proposed an advanced solution that can potentially be applied to thermal cancer therapy. An improved sensing technique for nanometer-scale heating and temperature sensing uses a chemical method to attach gold nanorods to the surface of a diamond nanocrystal, the authors have invented a new biocompatible nanodevice.
Authors: Ding Y, Zhou J, Wang S, Li Y, Mi Y, Gao S, Xu Y, Chen Y, Yan J Abstract Neuropilin-1 (NRP-1) is involved in a range of physiological and pathological processes, including neuronal cell guidance, cardiovascular development, immunity, angiogenesis and the pathogenesis of cancer. Targeting of NRP-1 is considered to be a potential cancer therapy and a number of approaches have been investigated, including the use of small interfering RNA, peptides, soluble NRP antagonists and monoclonal antibodies. The present study used a novel anti-neuropilin-1 monoclonal antibody (anti-NRP-1 mAb) to investigate its potentia...
We present in vitro evidence that HDACi can enhance the radiosensitivity of human thyroid cancer cells.
In this study, we compared the long-term side effects of proton radiation to equivalent doses of X-rays in the initiation and progression of premalignant lesions in a lung cancer susceptible mouse model (K-rasLA1). We show proton irradiation causes more complex DNA damage that is not completely repaired resulting in increased oxidative stress in the lungs both acutely and persistently. We further observed K-rasLA1 mice irradiated with protons had an increased number and size of initiated and premalignant lesions and adenomas that were often infiltrated with inflammatory cells. Proton irradiated mice had a lower median surv...
This article discusses the pathophysiology and molecular mechanisms that contribute to cancer therapeutics-related cardiac dysfunction and presents an napproach to the evaluation and treatment of these patients.
CONCLUSION: This approach merging qualitative and quantitative data suggests that mMCC patients report a better experience with avelumab than with chemotherapy. PMID: 30107762 [PubMed - as supplied by publisher]
Local Anesthetics as…Cancer Therapy? Anesth Analg. 2018 Sep;127(3):601-602 Authors: Lynch C PMID: 30113976 [PubMed - in process]
Publication date: Available online 17 August 2018Source: Biosensors and BioelectronicsAuthor(s): Haihua Wang, Mengjie Li, Yingning Zheng, Tao Hu, Yaqin Chai, Ruo YuanAbstractThough preferable progresses have been achieved to improve the photoelectric performance of fullerene (C60 NPs) by sensitized structure in photoelectrochemical (PEC) field, further application inevitably suffers from the inherent scarcities of heavy metal-involved quantum dots as sensitizers containing restricted sensitization effect, complex preparation and biological toxicity. In this work, a PEC biosensor based on [Ru(dcbpy)2dppz]2+/Rose Bengal dyes...
Photochem. Photobiol. Sci., 2018, Advance Article DOI: 10.1039/C8PP00271A, PerspectivePaula Garc ía Calavia, Gordon Bruce, Lluïsa Pérez-García, David A. Russell A review describing the state-of-the-art of the functionalisation of gold nanoparticles with photosensitisers and targeting ligands for photodynamic cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Veterans who seek care for low-risk prostate cancer receive more imaging that...Read more on AuntMinnie.comRelated Reading: Can AI best quantitative MRI in prostate lesions? Multiparametric MRI aids in prostate cancer follow-up SNMMI: Early prostate cancer therapy extends lives SNMMI: Fluciclovine-PET changes prostate treatment MRI-based risk model improves prostate cancer detection
Conclusions: Use of cam, particularly biologic products, increased significantly after a cancer diagnosis. Further studies are required to examine the effect of cam use on the efficacy and safety of cancer therapies. PMID: 30111972 [PubMed - in process]