Venlafaxine abuse

2.5 out of 5 stars Venlafaxine as the ‘baby ecstasy’? Literature overview and analysis of web-based misusers’ experiences. Francesconi G et al. Hum Psychopharmacol Clin Exp 2015 Jul;30:255-261.  Abstract In 2003, Sattar et al published a case report of venlafaxine abuse in a 38-year-old man. The patient had been prescribed 225-mg extended-release venlafaxine daily. He found that increasing his dose by 50% — to 337.5-mg per day — initially produced a “sudden, amphetamine-like ‘high'” that he did not re-experience even after increasing the dose to 450-mg. He subsequently discovered that crushing the pills produced greater effects, and he began ingesting up to 3600-mg daily (!) of crushed venlafaxine. After he ingested 4050-mg (!!) of crushed venlafaxine, he developed chest pain that required emergency department evaluation. He had tachycardia and hypertension on presentation, but these resolved and apparently no cardiac issues were identified. This goal of this current paper was to investigate reports of venlafaxine abuse, both in the medical literature and as described anecdotally on the following websites: Unfortunately, the 6 case reports the authors found in their literature search are described only vaguely, and the anecdotal reports were, well, anecdotal reports. However, there are some interesting points to b...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical abuse effexor overdose venlafaxine Source Type: news

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Authors: Ma W, Wang W, Huang X, Yao G, Jia Q, Shen J, Ouyang H, Chang Y, He J Abstract Red ginseng is often combined with Aconiti Lateralis Radix Praeparata to reduce alkaloids-related toxicity of the latter. Such herb-pairing also results in better therapeutic effect in heart failure, as compared to the singular use of either herb. The purpose of this study was to investigate the effect of Aconiti Lateralis Radix Praeparata and its combination with red ginseng on the activities of CYP450 enzymes in rats. A sensitive and reliable HPLC-MS/MS method was established and validated for the simultaneous determination of ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research
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