A case of methyl ethyl ketone peroxide poisoning and a review of complications and their management

Methyl Ethyl Ketone Peroxide (MEKP) is a highly toxic clear liquid used as a solvent. It is a strong oxidizing agent and a corrosive. Acute and chronic toxicity can occur as an occupational hazard. Ingestion is associated with corrosive burns leading to stricture formation, inhalational pneumonitis, acidosis, liver failure and renal failure. In this paper we present a case of a young patient who intentionally ingested MEKP. The patient developed multiple complications including proximal intestinal obstruction, acidosis and acute kidney injury. He was managed conservatively and recovered after a prolonged hospital stay. He had multiple inflammatory strictures on esophageal endoscopy, which improved over 3–6 moths.
Source: Journal of Occupational Medicine and Toxicology - Category: Occupational Health Authors: Source Type: research

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This study investigated whether this risk varied across months and/or methods of suicide. METHODS: Time, date, method (eg, firearm, poisoning), and demographic information for 35,338 suicides were collected from the National Violent Death Reporting System for the years 2003-2010. Time of fatal injury was grouped into 1-hour bins and compared to the estimated hourly proportion of the population awake from the American Time Use Survey for 2003-2010. Negative binomial modeling then generated hourly incidence risk ratios (IRRs) of suicide. Risks were then aggregated into 4 categories: morning (6:00 am to 11:59 am), afterno...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
More than four fifths (81%) of the British public are worried about meat quality standards being relaxed by ministers in pursuit of trade deals with the US and the rest of the world, according to polling from UNISON/Savanta ComRes published today (Thursday). Over half (52%) believe the government regulations for meat quality standards should be tightened following the UK’s departure from the EU. A third (34%) say the UK should maintain its current laws and just 3% say rules should be relaxed. The poll of more than 2,000 people was commissioned amid concerns the government could agree to import chicken washed in chlor...
Source: UNISON Health care news - Category: UK Health Authors: Tags: Article Source Type: news
Authors: Medeiros MC, Rocha N, Bandeira E, Dantas I, Chaves C, Oliveira M, Bandeira F Abstract Sclerostin (Scl) is an osteoblast-inhibiting glycoprotein that is secreted mainly by osteocytes and is regulated by hormonal changes and skeletal loading. Decreased physical function and high serum Scl concentrations have been reported in chronic renal failure patients but little is known to date about the differences between diabetic and non-diabetic patients on hemodialysis who are susceptible to both sarcopenia and bone fragility. Objective.To determine the prevalence of sarcopenia and its association with serum Scl co...
Source: International Journal of Nephrology - Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research
This article examines how the initial absence of scientific data on the physiologic effects of flamethrowers led to an inaccurate understanding of their let hality, and bizarre claims that one of history’s most horrific instruments of war was considered one of the more “humane” weapons on the battlefield.
Source: Military Medical Research - Category: International Medicine & Public Health Source Type: research
This study describes the clinical profile and recovery pattern of swallowing following inhalation burn injury. All patients admitted 2008 –2017 with confirmed inhalation burns on laryngoscopy and managed by speech-language pathology (SLP) were included. Initial dysphagia presentation and dysphagia recovery pattern were documented using the FOIS. Co-presence of dysphonia was determined clinically and rated present/absent. Persistent laryngeal/pharyngeal injury at 6 months was documented using laryngoscopy. Data were compared to published data from a large adult burn cohort. All patients with confirmed inhalation ...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
DISCUSSION: The pathogenesis of frontal sinus cholesteatoma varies based on its cause (congenital vs acquired). Clinical diagnosis remains challenging but is aided by nasal endoscopy, computed tomography, and magnetic resonance imaging. Historically, FSC has been managed by total extirpation through open approaches, which can entail substantial morbidity. With sophisticated endoscopic sinus instrumentation and image guidance, FSC can be successfully treated via an endoscopic approach. Serial débridements and washouts in an outpatient setting may adequately manage the residual disease in the postoperative period. ...
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
CONCLUSIONS: MiR-30c-5p evidently inhibited HG-induced EMT and renal fibrogenesis by down-regulation JAK1 in DN, providing a promising therapeutic strategy for the treatment of DN. PMID: 32096183 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Chromic acid is an industrial metal acid widely used for electroplating in alloy and dye production. It can cause serious skin burn and, if absorbed, may lead to acute chromium poisoning. Such poisoning cases appear rarely in the literature [ 1 ]. We n...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Word countfor the text: 495 (excluding title page, author contributions, funding, competing interests, references, and figure legend)
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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