Decellularized Versus Fresh-Frozen Allografts in Anterior Cruciate Ligament Reconstruction: An In Vitro Study in a Rabbit Model

Conclusion:
The use of pH-modified decellularized allografts compared with the common allografts resulted in better cellularity, vascularity, collagen matrix remolding, new bone formation around the graft, enhanced tendon-bone healing, and higher ultimate failure load and stiffness of the graft after ACL reconstruction in the rabbit model.

Clinical Relevance:
The pH-modified decellularized allograft may be a better graft option than the common fresh-frozen allograft for knee ligament reconstructions.

Source: The American Journal of Sports Medicine - July 31, 2015 Category: Sports Medicine Authors: Dong, S., Huangfu, X., Xie, G., Zhang, Y., Shen, P., Li, X., Qi, J., Zhao, J. Tags: Knee ligaments, ACL, Allografts Source Type: research