Brain and serum galanin, thyroid hormones, and TSH are not influenced by different photoperiod schedules in broiler chickens
Abstract The purpose of the present study was to evaluate the effect of three different light regimens on serum thyroid hormones (THs), thyroid-stimulating hormone (TSH), and galanin levels, as well as brain galanin concentration, of broiler chickens. To this end, three groups of 1-day-old Cobb 500 broiler chicks were used. Each group consisted of 20 chickens. The chicks were kept in separate light-proof controlled rooms. All birds were reared on continuous light until 1 week of age. Then, the first group was treated under a continuous lighting (CL) program (23L:1D); the second group treated under a non-intermittent restricted lighting program (NIL) (6L:18D from day 7 to 28, 23L:1D from day 29 to 42); and the third one treated under an intermittent lighting program (IL) (1L:3D cycles). Feed intake per group was recorded during the experiment. At the end of the experiment (42 days of age), the birds were bled. Sera were collected from both fasted and fed chicks of each group and thyroid hormones, TSH, and galanin levels determined. Thereafter, chicks were humanely slaughtered, and the brain was removed for evaluation of galanin levels. Serum T3, T4, and TSH of birds under different photoperiod schedules were not significantly different in both fasted and fed chicks (P > 0.05). T3 levels were significantly lower in fasted as compared with fed chicks in all groups (P
Conclusions: Results reveals that developed nitrendipine nanoemulsion gel overcomes the limitation of low penetration and accentuate permeation through albino Wistar rat skin. It was concluded that nanoemulsion gel could be utilized as a potential carrier for transdermal delivery of nitrendipine. PMID: 31976777 [PubMed - as supplied by publisher]
Authors: Rezaie Shirmard L, Ghofrani M, Bahari Javan N, Bayrami S, Tavassoli A, Rezaie A, Amini M, Kebriaee-Zadeh A, Rouini MR, Dinarvand R, Rafiee-Tehrani M, Dorkoosh FA Abstract Uncontrolled distribution of nanoparticles (NPs) within the body can significantly decrease the efficiency of drug therapy and is considered among the main restrictions of NPs application. The aim of this study was to develop a depot combination delivery system (CDS) containing fingolimod loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) NPs dispersed into a matrix of oleic acid-grafted-aminated alginate (OA-g-AAlg) to minimize ...
Authors: Yoshida T, Sako K, Kondo H Abstract High consumption of oil formulations has been reported to reduce the blood exposure of drugs like tacrolimus. Consumption of oil formulations has also been shown to inhibit T-cell production of interleukin-2 (IL-2) compared to solid dispersion formulations (SDFs). However, a large amount of oil causes gastrointestinal side effects such as diarrhea and low compliance. Here, we investigated the feasibility of reducing the amount of oil and substitution of chemically synthetized oils for natural oils in these formulations. Reducing the amount of sunflower oil increased bloo...
CONCLUSIONS: In conclusion, the potential for supersaturation in LBDDS, and the risk of precipitation, was found to be highly drug dependent. The apparent degree of supersaturation was considered a major factor impacting the ability to maintain drug supersaturation upon storage. PMID: 31975613 [PubMed - as supplied by publisher]
Authors: Mailhot Vega RB, Hoppe BS PMID: 31976780 [PubMed - as supplied by publisher]
With a second case of a deadly Chinese virus confirmed in the United States, and four cases under investigation in New York, Buffalo-area hospitals are on alert and preparing as best as they can. The novel coronavirus was first identified in Wuhan, China, in December. More than 850 cases have since been reported worldwide, with more than 40 deaths in China. Transportation has been shutdown with travel restricted for millions in that country as international officials work to contain the di sease. In…