Optimal fractionation in radiotherapy for non-small cell lung cancer - a modelling approach.

CONCLUSIONS: For well oxygenated tumours, heterogeneous fractionation schedules could increase local control rates substantially compared to CFRT. For hypoxic tumours, SBRT-like hypofractionated schedules might be optimal despite the increased risk of intra-fraction repair due to a synergistic effect with inter-fraction reoxygenation.
PMID: 26217986 [PubMed - as supplied by publisher]

Source: Acta Oncologica - July 28, 2015 Category: Cancer & Oncology Authors: Lindblom E, Dasu A, Toma-Dasu I Tags: Acta Oncol Source Type: research