Effects of geographic scale on population factors in acute disease diffusion analysis

Conclusions We concluded that variables at suitable spatial resolution may be useful in improving the predictive powers of models for disease outbreaks.
Source: Journal of Acute Disease - Category: Emergency Medicine Source Type: research

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Influenza is an illness that affects individuals of all ages but its severity varies immensely: from the symptoms of a common cold to the deadly outbreak of the pandemic H1N1 strain in 2009. This case report describes the circumstances surrounding the critical illness of a healthy 7-year-old child who developed a massive air leak syndrome secondary to influenza B. She required the emergent insertion of a chest tube as well as intubation and mechanical ventilation. She developed severe acute respiratory distress syndrome and was strongly considered for being placed on extracorporeal membrane oxygenation.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
The acute inflammatory lung injury is an important cause of death due to influenza A virus (IAV) infection. Insulin-like growth factor 1 (IGF1) played an important role in the regulation of inflammation in the immune system. To investigate the role of IGF1 in IAV-mediated acute inflammatory lung injury, the expression of IGF1 and inflammatory cytokines was tested after IAV A/Puerto Rico/8/1934 (H1N1; abbreviated as PR8) infection in A549 cells. Then, a BALB/c mouse model of PR8 infection was established. On days 3, 5, 7, and 9 post-infection, the mice lung tissue was collected to detect the expression changes in IGF1 mRNA ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Hadjichristodoulou A scoping search and a systematic literature review were conducted to give an insight on entry and exit screening referring to travelers at points of entry, by analyzing published evidence on practices, guidelines, and experiences in the past 15 years worldwide. Grey literature, PubMed. and Scopus were searched using specific terms. Most of the available data identified through the systematic literature review concerned entry screening measures at airports. Little evidence is available about entry and exit screening measure implementation and effectiveness at ports and ground crossings. Exit screen...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Publication date: Available online 9 November 2019Source: Canadian Journal of CardiologyAuthor(s): Julien Guihaire, Francois Haddad, Mita Hoppenfeld, Myriam Amsallem, Jeffrey W. Christle, Clark Owyang, Khizer Shaikh, Joe L. HsuAbstractMechanical circulatory support (MCS) has made rapid progress over the last three decades. This was driven by the need to develop acute and chronic circulatory support as well as by the limited organ availability for heart transplantation. The growth of MCS was also driven by the use of extracorporeal membrane oxygenation (ECMO) after the worldwide H1N1 influenza outbreak of 2009. The majority...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
A recent study in this journal compared codon usage among NA subtypes (N1, N2, N6, and N8)  of H5Nx highly pathogenic avian influenza A viruses (HPAIVs) and suggested that codon usage in N1 subtype is better adapted to its host than the epidemic NA subtypes (N6 and N8), which had fewer number of human cases compared to the N1 subtype.1 To date, there are 18 known HA subtypes (H1-H18) and 11 known NA subtypes (N1-N11)2. However, only N1 and N2 subtypes have been reported to cause pandemics (H1N1 for the 1918 and 2009 pandemics; H2N2 for the 1957 pandemic; and H3N2 for the 1968 pandemic) or seasonal outbreaks in humans3.
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
This article provides the groundwork and insights as a value addition toward an India-specific framework of action for response and recovery for Nipah outbreaks in future.
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
Armando Isibasi Constantino López-Macías The clinical effects and immunological response to the influenza vaccine in women who later become pregnant remain to be thoroughly studied. Here, we report the medical outcomes of 40 women volunteers who became pregnant after vaccination with an experimental virus-like particle (VLP) vaccine against pandemic influenza A(H1N1)2009 (influenza A(H1N1)pdm09) and their infants. When included in the VLP vaccine trial, none of the women were pregnant and were randomly assigned to one of the following groups: (1) placebo, (2) 15 μg dose of VLP vaccine, or (3) ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
We present a tool for estimating the reproduction number in real-time during infectious disease outbreaks accurately, which is available as an R software package (EpiEstim 2.2). It is also accessible as an interactive, user-friendly online interface (EpiEstim App), permitting its use by non-specialists. Our tool is easy to apply for assessing the transmission potential, and hence informing control, during future outbreaks of a wide range of invading pathogens.
Source: Epidemics - Category: Epidemiology Source Type: research
Conclusions: Regular molecular surveillance of influenza A(H1N1)pdm09 is important to monitor the viral behavior in terms of increase virulence, drug resistance pattern and emergence of novel strains.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
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