Yale study identifies 'major player' in skin cancer genes

(Yale University) A multidisciplinary team at Yale, led by Yale Cancer Center members, has defined a subgroup of genetic mutations that are present in a significant number of melanoma skin cancer cases. Their findings shed light on an important mutation in this deadly disease, and may lead to more targeted anti-cancer therapies.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Conclusions: Early favorable signs of FDG-PET parameters may vary among diseases with immune checkpoint inhibitors. Mean FDG uptake was elevated in several immune-related organs at the early restaging scan. Among them, elevated FDG accumulation in thyroid might be a candidate sign of monitoring effectiveness of immunotherapy observed earlier than immune-related lymphadenopathy. Relationship between % change () of PET parameters and patients outcome% chage (Î") of PET parametersMalignant melanoma(Odds, 95%CI, p)Malignant lymphoma (Odds, 95%CI, p)Renal cell carcinoma (Odds, 95%CI, p)Î&quo...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors Source Type: research
AbstractHyperthermia is a promising alternative modality for the conventional cancer treatments. Nanoparticle-mediated photothermal therapy (PTT) has been widely applied for hyperthermia cancer therapy by a near-infrared light irradiation. Some special nanoparticles can convert light energy into heat and destroy the tumor cells. Inspired from the photothermal efficacy of the gold nanoparticles, here we synthesized, characterized, and applied novel photothermal polyethylene glycol-curcumin-gold nanoparticles (PEG-Cur-Au NPs) in cancer PTT. The effect of PEG-Cur-Au NPs upon irradiation by an 808-nm laser on C540 (B16/F10) ce...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
Publication date: Available online 30 April 2018 Source:Seminars in Cancer Biology Author(s): Tobias Gutting, Elke Burgermeister, Nicolai Härtel, Matthias P. Ebert Immunotherapy is the latest revolution in cancer therapy. It continues to show impressive results in malignancies like melanoma and others. At least so far, effects are modest in colorectal cancer (CRC) and only a subset of patients benefits from already approved checkpoint inhibitors. In this review, we discuss major hurdles of immunotherapy like the immunosuppressive niche and low immunogenicity of CRC next to current achievements of checkpoint inhibitor...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Abstract In the present study, the potential of doxorubicin hydrochloride (DOX)-loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers was studied to investigate the simultaneous effect of hyperthermia and chemotherapy against melanoma cancer B16F10 cell lines. The cobalt ferrite nanoparticles were synthesized via microwave heating method. The titanium oxide nanoparticles were mixed with cobalt ferrite to control the temperature rise. The synthesized nanoparticles and nanofibers were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and vibrating sample...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
The majority of cancer deaths are associated with metastasis, the process of cancer cells spreading from primary tumor sites and forming new tumors at distant organs. Circulating tumor cells (CTCs) are the key determinants of metastatic propensity. Detection and characterization of CTCs is critical for understanding tumor metastasis and improving cancer therapy. Here, we applied a linear-array-based photoacoustic tomography (LA-PAT) system for label-free high-throughput melanoma CTC imaging in patients in vivo.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research
Little is known about the impact of melanoma stage and treatment on quality of life (QoL).The Functional Assessment of Cancer Therapy Melanoma (FACT-M) was completed by 87 patients at an academic institution in 2015-2016. Scores were compared between localized and advanced-stage patients. FACT-M scores were converted to European Quality of Life-5 Dimensions (EQ-5D) scores for derivation of health utilities. Melanoma was associated with reduced utility compared to the general population (0.76 vs 0.87, respectively).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research
Conclusion We report the clinical and genomic landscape of a patient with MPTs who had no identifiable unique somatic or germline mutations to explain her predilection to cancer. The treatment course and overall prognosis for this patient is important for understanding future cases with unrelated, metachronous MPTs, the occurrence of which cannot always be explained by underlying genetic mechanisms.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
The majority of cancer deaths are associated with metastasis, the process of cancer cells spreading from primary tumor sites and forming new tumors at distant organs. Circulating tumor cells (CTCs) are the key determinants of metastatic propensity. Detection and characterization of CTCs is critical for understanding tumor metastasis and improving cancer therapy. Here, we applied a linear-array-based photoacoustic tomography (LA-PAT) system for label-free high-throughput melanoma CTC imaging in patients in vivo.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research
Little is known about the impact of melanoma stage and treatment on quality of life (QoL).The Functional Assessment of Cancer Therapy Melanoma (FACT-M) was completed by 87 patients at an academic institution in 2015-2016. Scores were compared between localized and advanced-stage patients. FACT-M scores were converted to European Quality of Life-5 Dimensions (EQ-5D) scores for derivation of health utilities. Melanoma was associated with reduced utility compared to the general population (0.76 vs 0.87, respectively).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research
FINDINGSMelanoma, a relatively rare but deadly skin cancer, has been shown to switch differentiation states — that is, to regress to an earlier stage of development — which can lead it to become resistant to treatment. Now, UCLA researchers have found that melanomas can be divided into four distinct subtypes according to their stages of differentiation. Cell subtypes that de-differentiated — meaning that they reverted back to a less-mature cell — showed sensitivity to a type of self-inflicted cell death called ferroptosis.The research also showed that certain subtypes of melanoma cells could be succ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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