Novel way of protecting male reproductive cells discovered, hails new approach to addressing male infertility

A potential avenue to protect male germ cells against heat stress by applying an external source of hydrogen sulphide has been identified by researchers. The findings may provide a new approach to treating male infertility.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: Available online 21 July 2018Source: Small Ruminant ResearchAuthor(s): Jeanette Olejnik, Natalka Suchowerska, Muren Herrid, Michael Jackson, Geoff Hinch, Jonathan HillAbstractMany alternatives to surgical castration have been explored to induce short or long term infertility in male animals. Comparatively few have been carefully evaluated in very young production animals. A comparison of four treatments known to deplete testicular cells in rodents (heating, cooling, chemotherapy, radiation) was undertaken using ram lambs.Neither testicular cooling (0 °C) nor heating (45 °C) affected ...
Source: Small Ruminant Research - Category: Zoology Source Type: research
A patient sent me this email.-----Original Message-----From:To: Aniruddha MalpaniSubject: Re: Two ivf cycles failedSir,Can U pls suggest ivf success supplements?Next month I m going for third cycleCan I use mothers Horlicks?How to get good eggs and embryos?Any diet chart before, during and after embryo transfer?Sir, pls kindly suggest meLifelong I will be really thankful to youNow I m taking1. apcod sachets2. Metformin3. Normoz4. Ultra CoQ105. Folic acidMy previous ivf failure reasons are poor quality eggs and embryos, implantation failure and may be unexplained infertility reason Actually, the most likely reason for ...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Fertility treatments for me have never been an easy experience...unnecessary tests, lot of doubts, unsure about the doctors approach, too many strong hormones injected due to an assembly line approach and in the end ...an unsatisfactory feeling.We have been very impressed with Dr. Malpani's interactive and amazing website.  All our doubts were answered regularly by visiting and writing out our queries on the website. Our beginning itself was so easy and we could feel and appreciate the Doctors' expert knowledge in the field of infertility.We are blessed with a healthy and adorable baby, on my first try, inspite of my ...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
AbstractPurpose of ReviewOpioids are the cornerstone for pain treatment with significant recent increases in the number of prescriptions. Sexual dysfunction (SD) is a major side effect of opioid therapy. The goal of this review is to examine the current literature on the effects of opioids on male SD (erectile dysfunction [ED], hypogonadism, ejaculatory dysfunction) and infertility.Recent FindingsHigh prevalence of SD exists in men with opioid use as compared to the general population, with an abundance of evidence suggesting an association between opioid use and ED and hypogonadism. There appears to be a role for testoste...
Source: Current Sexual Health Reports - Category: Sexual Medicine Source Type: research
AbstractTesticular apoptotic cell death (TACD) contributes to diabetes  mellitus (DM)-induced male infertility. MicroRNA-34a (miR-34a) is a pro-apoptotic RNA that targets sirtuin 1 (SIRT1) which provides protection against complications of (DM). However, the specific role of miR-34a in (DM)-induced TACD is unknown. MiR-34a targetsSirt1 mRNA, resulting in apoptosis. However, whether or not SIRT1 is a major target of miR-34a in (DM)-induced TACD is unclear. The present study aimed to define the role of miR-34a/SIRT1 in (DM)-induced TACD. C57BL/6 male mice were induced to (DM) by streptozotocin, for a period of 24  ...
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research
CONCLUSIONS: Unbalanced production of Cho signal in the follicular fluid may have occurred secondary to membrane damage of cumulus-oocyte-complexes due to CC therapy. PMID: 30024629 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
UK campaigners Fertility Network UK say the invention of IVF is less of an achievement because not enough people have full access to the treatment which helps infertile people to conceive.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionsOur finding of an increased risk of HGSC associated with PID lends support to the hypothesis that inflammatory processes may be involved in the etiology of HGSC.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Unfortunately, the first author name was incorrectly published in the original publication. The complete correct name should read as follows.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
ConclusionsAge of the mother, outcome of the first pregnancy, and treatment factors affect the length of the interpregnancy interval. Because short IPI has been associated with poor outcomes, women who are at risk for short IPI should be counseled about these outcome risks.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
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