Opposite effects of angiotensins receptors type 2 and type 4 on streptozotocin induced diabetes vascular alterations in mice

Conclusions:
The results suggest an opposite contribution of AT2 and AT4 receptors to the vascular alterations caused by streptozotocin-induced diabetes in mice, since chronic stimulation of AT4 by AngIV and inhibition of AT2 similarly reverse diabetes-induced endothelial dysfunction and hypertrophic remodeling, and increase NO bioavailability.

Source: Cardiovascular Diabetology - February 10, 2014 Category: Cardiology Authors: Mohamad NasserNicolas ClereLaurent BotelleJames JavellaudNicole OudartSébastien FaureJean-Michel Achard Source Type: research