Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia - a simulation study.

CONCLUSIONS: In line with recent experimental and clinical data, the results suggest that HX4 is a promising new tracer that provides high image contrast four hours p.i., though inter-patient variance can be very high. Nevertheless, the widely used tracer FMISO provides a robust and reproducible signal four hours p.i., but with a lower contrast. The simulations revealed tracer clearance to be the key factor in determining image contrast. PMID: 26203928 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26203928?dopt=Abstract

Source: Acta Oncologica - July 23, 2015 Category: Cancer & Oncology Authors: Wack LJ, Mönnich D, van Elmpt W, Zegers CM, Troost EG, Zips D, Thorwarth D Tags: Acta Oncol Source Type: research