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FDA approves Technivie for treatment of chronic hepatitis C genotype 4

The U.S. Food and Drug Administration today approved Technivie (ombitasvir, paritaprevir and ritonavir) for use in combination with ribavirin for the treatment of hepatitis C virus (HCV) genotype 4 infections in patients without scarring and poor liver function (cirrhosis).
Source: Food and Drug Administration - Category: American Health Source Type: news

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This study compared sustained virological response (SVR) rates and proportion of lost to follow‐up (LTFU) between OST and non‐OST patients in the German Hepatitis C‐Registry (DHC‐R). DesignNational multi‐centre prospective real‐world registry (German Hepatitis C‐Registry, DHC‐R). Non‐OST patients comprised patients with former/current drug use (non‐OST/DU) and patients never consuming drugs (non‐OST/NDU). SettingA total of 254 medical centres in Germany, including 123 centres providing OST. ParticipantsA total of 7747 chronic HCV patients started DAA therapy (739 OST and 7008 non‐OST; 1500 non‐OST...
Source: Addiction - Category: Addiction Authors: Tags: Research Report Source Type: research
We have read your article by Singal et  al1 with great interest, which discussed hepatocellular carcinoma screening being associated with early tumor detection and improved survival among patients with cirrhosis in the United States. The study clearly highlighted the importance of performing hepatocellular carcinoma screening in patient s with cirrhosis; however, what is of concern is that more than half of the cases of hepatocellular carcinoma were found secondary to symptoms or incidentally, rather than through the hepatocellular carcinoma screening algorithm.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Letter Source Type: research
This article is protected by copyright. All rights reserved
Source: Journal of Medical Virology - Category: Virology Authors: Tags: Research Article Source Type: research
Conclusions: In this study of cirrhotic patients and healthy controls from USA and Turkey, a diet rich in fermented milk, vegetables, cereals, coffee and tea, is associated with a higher microbial diversity. Microbial diversity was associated with an independently lower risk of 90‐day hospitalizations. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research
Abstract Background and AimsGenotype 1 chronic hepatitis C is associated with an impairment of glucose homoeostasis, especially in the advanced stages of the disease. Glucose tolerance is an independent predictor of liver‐related mortality in patients with cirrhosis because of chronic hepatitis C. However, no study has demonstrated so far weather hepatitis C virus clearance affects glucose tolerance. MethodsTo this aim, we performed a prospective study assessing the effects of direct antiviral agents treatment in nondiabetic cirrhotic patients with genotypes 1a/1b and impaired glucose tolerance based on a 75‐g oral glu...
Source: Liver International - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractHepatitis C virus (HCV) infection is a significant health problem worldwide, and is the leading cause of cirrhosis, hepatocellular carcinoma, and liver transplantation in the United States. The management of HCV has changed significantly over the last 5  years, as treatments have become simpler and more efficacious. Medication efficacy is now greater than 90%, with a high barrier to resistance and few side effects. This review is a collaboration between primary care and hepatology providers to explore all aspects of HCV management: acute versus ch ronic HCV infection, transmission and testing, and diagnosis an...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Abstract PURPOSE OF REVIEW: Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease globally and nonalcoholic steatohepatitis is projected to become the most common indication for liver transplantation. The purpose of this review is to highlight key issues surrounding NAFLD as an indication for liver transplantation, including its increasing prevalence, outcomes related to liver transplantation, development of post liver transplant NAFLD and NAFLD in the liver donor pool. RECENT FINDINGS: With the advent of direct-acting antiviral therapies, the proportion of patients on the liver...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
Conclusion: This heterogeneous cohort of coinfected patients showed a high rate of SVR12. Among cirrhotic patients, those with a liver stiffness at least 21 kPa had a higher probability of treatment failure. Ribavirin use seems to increase the appearance of adverse events.
Source: AIDS - Category: Infectious Diseases Tags: Clinical Science Source Type: research
ConclusionsElbasvir/grazoprevir for 12  weeks represents an effective treatment option for participants with HCV GT1b infection. SVR12 was high in all participant subgroups, including those with compensated cirrhosis, HIV co-infection, and high baseline viral load.ClinicalTrials.gov identifiersThe trials discussed in this paper were registered with Clinicaltrial.gov as the following: NCT02092350 (C-SURFER), NCT02105662 (C-EDGE Co-Infection), NCT02105467 (C-EDGE treatment-naive), NCT02105701 (C-EDGE treatment-experienced), NCT01717326 (C-WORTHy), NCT02251990 (C-CORAL), NCT02105688 (C-EDGE COSTAR), NCT02252016 (C-EDGE I...
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Abstract BACKGROUND:  With regard to quality of life and organ shortage, follow-up after liver transplantation (LT) should consider risk factors for allograft failure in order to avoid the need for re-LT and to improve the long-term outcome of recipients. Therefore, the aim of this study was to explore potential risk factors for allograft failure after LT. MATERIAL AND METHODS:  A total of 489 consecutive LT recipients who received follow-up care at the University Hospital of Muenster were included in this study. Database research was performed, and patient data were retrospectively reviewed. Risk f...
Source: Zeitschrift fur Gastroenterologie - Category: Gastroenterology Authors: Tags: Z Gastroenterol Source Type: research
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