Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis

Conclusion These data confirm that GABA-transporter expression is spatially and isoform-specific reduced and GABA-transporter 3 positive cell numbers are unchanged in hippocampal sclerosis. Implications for the use of GABAergic antiepileptic therapies in hippocampal sclerosis vs non-hippocampal sclerosis patients remain to be studied.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research