Gender and Age Related Changes in Number of Dopaminergic Neurons in Adult Human Olfactory Bulb

Conclusion Factors such as gender and age may affect the number of dopaminergic neurons, and there is a correlation between increased dopaminergic neurons and olfactory performance. Moreover, the increase in dopaminergic cells in the olfactory bulb of the elderly may indicate the existence of rostral migratory stream in adult humans.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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This study was registered with the Chinese Clinical Trial Registry under ChiCTR-TRC-14004707. Registered on May 27, 2014.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
The system may now be used to target patients'internal globus pallidus, a portion of the brain associated with Parkinson's disease symptoms.
Source: mobihealthnews - Category: Information Technology Source Type: news
By 'rewinding' cells of early-onset Parkinson's disease patients back to their stem cell states, a Cedars-Sinai study found that, even as embryos, theyhad abnormal dopamine neurons.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(Rutgers University) A collaboration between scientists at Rutgers University and Scripps Research leads to the discovery of a small molecule that may slow down or stop the progression of Parkinson's disease
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Cedars-Sinai Medical Center) People who develop Parkinson's disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to EMBARGOED Cedars-Sinai research that will publish Jan. 27 in the journal Nature Medicine. The research points to a drug that potentially might help correct these disease processes.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsPD patients report more prevalent and severe GI dysfunction, although our cohort comprised of many later-stage participants. Earlier recognition of GI dysfunction in PD provides the opportunity to direct treatment for chronic pain and constipation, promote physical activity and rationalise PD therapies for optimal patient care.
Source: Journal of Neurology - Category: Neurology Source Type: research
A stooped posture is a main clinical feature of Parkinson's disease (PD). The assessment of posture is important to measure treatment effects. The aim of this study was to investigate the reliability of a standardized postural rating tool, to calculate minimal detectable change scores and to assess the role of gender and age.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
AbstractThe clinical pictures of essential tremor (ET) with resting tremor (rET) and tremor-dominant Parkinson ’s disease (tPD) are often quite mimic at the early stage, current approaches to the diagnosis and treatment therefore remain challenging. The regional homogeneity (ReHo) method under resting-state functional magnetic resonance imaging (rs-fMRI) would help exhibit the patterns in neural activity, which further contribute to differentiate these disorders and explore the relationship between symptoms and regional functional abnormalities. Sixty-eight Chinese participants were recruited, including 19 rET patien...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We examined whether Rhy promotes this regulation in bone marrow human mesenchymal stromal cells (BM-hMSCs). Results revealed (i) Rhy modulated biological activity by regulating the mitochondria, N-methyl-D-aspartate receptor subunit, and levels of FGFβ (basic fibroblast growth factor), BDNF (brain-derived neurotrophic factor), OXTR (oxytocin receptor) and ATP (Adenosine triphosphate); (ii) Rhy altered expression level of BM-MSC proliferation/differentiation-related transcription genes; and (iii) interestingly, Rhy amplified the glycolytic flow ratio and lactate dehydrogenase activity while reducing pyruvate dehydrogen...
Source: Cytotherapy - Category: Cytology Source Type: research
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