Proliferative vitreoretinopathy: a new concept of disease pathogenesis and practical consequences

Publication date: Available online 21 July 2015 Source:Progress in Retinal and Eye Research Author(s): J.Carlos Pastor, Jimena Rojas, Salvador Pastor-Idoate, Salvatore Di Lauro, Lucia Gonzalez-Buendia, Santiago Delgado-Tirado During the last four decades, proliferative vitreoretinopathy (PVR) has defied the efforts of many researchers to prevent its occurrence or development. Thus, PVR is still the major complication following retinal detachment (RD) surgery and a bottle-neck for advances in cell therapy that require intraocular surgery. In this review we tried to combine basic and clinical knowledge, as an example of translational research, providing new and practical information for clinicians. PVR was defined as the proliferation of cells after RD. This idea was used for classifying PVR and also for designing experimental models used for testing many drugs, none of which were successful in humans. We summarize current information regarding the pathogenic events that follow any RD because this information may be the key for understanding and treating the earliest stages of PVR. A major focus is made on the intraretinal changes derived mainly from retinal glial cell reactivity. These responses can lead to intraretinal PVR, an entity that has not been clearly recognized. Inflammation is one of the major components of PVR, and we describe new genetic biomarkers that have the potential to predict its development. New treatment approaches are analyzed, especially...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research