Impact of age on aortic wave reflection responses to metaboreflex activation and its relationship with leg lean mass in postmenopausal women.

Impact of age on aortic wave reflection responses to metaboreflex activation and its relationship with leg lean mass in postmenopausal women. Exp Gerontol. 2015 Jul 17; Authors: Figueroa A, Jaime SJ, Johnson SA, Alvarez-Alvarado S, Campbell JC, Feresin RG, Elam ML, Arjmandi BH Abstract Wave reflection (augmentation pressure [AP] and index [AIx]) is greater in older women than men. Resting AP is a better wave reflection index than AIx in older adults. The negative relationship between wave reflection and lean mass (LM) has been inconsistent. We investigated the impact of age and LM on aortic hemodynamic responses to metaboreflex activation in postmenopausal women. Postmenopausal women, younger and older (n=20 per group) than 60years, performed 2-min isometric handgrip at 30% of maximal force followed by 3-min post-exercise muscle ischemia (PEMI). We measured carotid-femoral pulse wave velocity (cfPWV) and femoral-ankle PWV (faPWV) at rest, and aortic systolic blood pressure (aSBP), pulse pressure (aPP), AP, AIx, and AIx-adjusted for heart rate (AIx@75) at rest and during PEMI using tonometry. Arm and leg LM were measured by DEXA. Resting cfPWV, aSBP, and aPP were higher, while AIx@75 and leg LM were lower in older than younger women. aSBP and aPP increased similarly during PEMI in both groups. Increases in AP (P<0.05), AIx (P<0.05), and AIx@75 (P<0.01) during PEMI were greater in older than younger women. From these responses...
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research