Estimating Time-Varying PCB Exposures Using Person-Specific Predictions to Supplement Measured Values: A Comparison of Observed and Predicted Values in Two Cohorts of Norwegian Women

Conclusions: The mechanistic model reproduced all measurements of PCB concentrations within a factor of ten and subject ranking and quartile assignments were overall largely consistent, although weak within each study group. Contamination histories for individuals predicted by CoZMoMAN revealed variation between study subjects, particularly in the timing of peak concentrations. Mechanistic models provide individual PCB exposure metrics that could serve as valuable supplements to measurements. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Nøst TH, Breivik K, Wania F, Rylander C, Odland JØ, Sandanger TM. Estimating Time-Varying PCB Exposures Using Person-Specific Predictions to Supplement Measured Values: A Comparison of Observed and Predicted Values in Two Cohorts of Norwegian Women. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1409191. Received: 8 September 2014 Accepted: 13 July 2015 Advance Publication: 17 July 2015 EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may n...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research