MicroRNAs: What cardiologists should know about them?

[MicroRNAs: What cardiologists should know about them?] Presse Med. 2015 Jul 8; Authors: Mericskay M Abstract MiRNAs are small 21-22 nucleotides long RNAs transcribed from non coding genes or introns of coding genes that are involved the repression of cellular messenger RNAs by the RISC complex. Close to 2000 miRNAs have been identified in the human genome and the expression of hundreds of them is increased or decreased in pathological condition, modifying on a global scale the expression of cardiac and vascular proteins. MiRNAs regulate most cellular processes involved in the cardiovascular pathophysiology including apoptosis, proliferation and migration, left ventricle hypertrophy, cardiac fibrosis and conduction. MiRNAs form a new class of therapeutic targets that can be introduced in the cells in various forms (synthetic molecules, expression vectors) or inhibited by antisens oligonucleotides called anti-miRs. MiRNAs are actively secreted by specific cells including cardiac fibroblasts and endothelial cells during certain pathophysiological processes, or passively following cell death and can be quantified in all kind of body fluids. They emerge as a new category of cardiovascular disease biomarkers, notably in the context of myocardial infarction. PMID: 26163829 [PubMed - as supplied by publisher]
Source: Presse Medicale - Category: Journals (General) Authors: Tags: Presse Med Source Type: research

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Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): Wan Bei, Li Jing, Nie ChenAbstractWogonin, one of the main active ingredients of Scutellaria radix, is a kind of flavonoid compound. In the present study, we report that wogonin nanoparticles (Wog np) protect Isoproterenol (ISO) induced Myocardial Infarction (MI) rats. Nanoparticles of sizes less than 200 nm with spherical shape were prepared using Polylactic-co-glycolic acid (PLGA) and Polyvinyl alcohol (PVA) respectively as polymer and stabilizer. Male Wistar rats were divided into 4 groups. Group 1 as a control group a...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Herz - Category: Cardiology Tags: Herz Source Type: research
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Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Authors: Lionetti V, Barile L Abstract Over the last 20 years increasing number of patients with multimorbidity and polypharmacy underwent different types of elective non-cardiac and cardiac surgery. Despite surgery is safer today than in the past, rate of perioperative major adverse cardiovascular events is still attracting significant attention from both clinicians and researchers. The perioperative myocardial infarction (PMI), a permanent damage of the heart, is a major cause of short and long term morbidity and mortality in current surgical populations. Although it is primarily the result of local myocardial is...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
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Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
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Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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