Risk factors for colistin-associated acute kidney injury: a multicenter study from Turkey.

Risk factors for colistin-associated acute kidney injury: a multicenter study from Turkey. Jpn J Infect Dis. 2015 Jul 10; Authors: Gul S, Kuscu F, Aydemir H, Ozturk DB, Deveci O, Duygu F, Kacmaz B, Yaman F, Aslan E Abstract The aim of this study was to investigate the incidence of acute kidney injury (AKI) and its risk factors due to colistin use in patients infected with multi-drug resistant pathogens. This multicenter, retrospective, observational study was conducted in Turkey at five different research and university hospitals. Cox-regression analyses were performed, to determine independent predictors of acute kidney injury. From April 2012 to July 2014, a total of 216 patients aged between 18-94 years, treated with colistimethate sodium (CMS) were included in the study. The mean age of the patients was 60.3±20.1, ranging between 18-94 years. The overall incidence of AKI was 34.3% (74/216) at any time during treatment. Results of the Cox regression analysis indicated that concomitant use of loop diuretics, baseline creatinin level and CMS dosage were independently associated with AKI. According to our results, patients with higher baseline creatinin levels or patients who have to use concomitant loop diuretics may be monitored more closely and dose adjustment should be done promptly. Additionally, more comprehensive studies are needed into the efficacy of low dose colistin since the higher doses increase the risk of AKI. ...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research