Vitamin D status is associated with skin autofluorescence in patients with type 2 diabetes mellitus: a preliminary report

Background: Skin autofluorescence is a non-invasive measurement of advanced glycation end products (AGE), which are suggested to be one of the major agents in the pathogenesis and progression of diabetes related cardiovascular complications. Recently, low vitamin D status has been linked to the progression of type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this study is to investigate the association between vitamin D status and skin autofluorescence in patients with T2DM. Methods: In this preliminary report skin autofluorescence was measured non-invasively with an AGE-reader in 245 patients with T2DM treated with lifestyle advice, metformin and/or sulphonylurea-derivatives. All patients were randomly assigned to receive either vitamin D 50,000 IU/month or placebo for 6 months. Results: Skin autofluorescence was significantly higher in patients with a serum 25(OH)D 75 nmol/l (2.81 versus 2.41; p 
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research