Modulation of nuclear receptor function by cellular redox poise.

Modulation of nuclear receptor function by cellular redox poise.
J Inorg Biochem. 2014 Jan 21;
Authors: Carter EL, Ragsdale SW
Abstract
Nuclear receptors (NRs) are ligand-responsive transcription factors involved in diverse cellular processes ranging from metabolism to circadian rhythms. This review focuses on NRs that contain redox-active thiol groups, a common feature within the superfamily. We will begin by describing NRs, how they regulate various cellular processes and how binding ligands, corepressors and/or coactivators modulate their activity. We will then describe the general area of redox regulation, especially as it pertains to thiol-disulfide interconversion and the cellular systems that respond to and govern this redox equilibrium. Lastly, we will discuss specific examples of NRs whose activities are regulated by redox-active thiols. Glucocorticoid, estrogen, and the heme-responsive receptor, Rev-erb, will be described in the most detail as they exhibit archetypal redox regulatory mechanisms.
PMID: 24495544 [PubMed - as supplied by publisher]

Source: Journal of Inorganic Biochemistry - January 21, 2014 Category: Biochemistry Authors: Carter EL, Ragsdale SW Tags: J Inorg Biochem Source Type: research