High Fat Diet impairs the function of Glucagon-like Peptide-1 producing L-cells

Conclusion Mice fed on HFD exhibited reduced expression in L-cells of many L-cell specific genes, suggesting an impairment of enteroendocrine cell function. Our results suggest that a western style diet may detrimentally affect the secretion of gut hormones and normal post-prandial signalling, which could impact on insulin secretion and satiety.

Source: Peptides - July 14, 2015 Category: Biochemistry Source Type: research