Endobronchial lipoma mimicking bronchial carcinoid tumour

A 68-year-old smoker on aspirin/clopidogrel due to recent percutaneous coronary intervention (PCI) /stenting presented with intermittent haemoptysis. Bronchoscopy revealed an endoluminal tumour in a right-lower-lobe segment (figure 1). No biopsy was taken due to bleeding risk. Aspirate analysis showed sparse cells with granular cytoplasm, and a presumptive diagnosis of bronchial carcinoid was made. CT scan showed no lymphadenopathy. After stopping clopidogrel and absent signs for progression on CT scan/bronchoscopy, right-lower lobectomy was performed. Histological analysis revealed a submucosal lipoma (figure 2). Differential diagnosis of endobronchial tumours encompasses benign (eg hamartoma, lipoma)1 and malignant lesions (eg bronchial carcinoid, metastasis, mucoepidermoid or adenocystic carcinoma).2 Biopsy has to be weighed against bleeding risk especially if a bronchial carcinoid is considered. Retrospectively, a lipoma could have been suspected based on the density of the lesion (–122 HU) and the endoscopic appearance. The management of...
Source: Thorax - Category: Respiratory Medicine Authors: Tags: Images in Thorax, Journalology, Hemoptysis, Screening (oncology), Airway biology, Cardiothoracic surgery, Radiology (diagnostics), Ethics, Health education, Smoking, Health effects of tobacco use, Tobacco use Chest clinic Source Type: research

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Conclusion. The lipomyelocele spectrum and to some degree all of the malformations discussed, even though they may not share gross appearance, anatomic site, surgical approach, or prognosis, require clinical and histopathologic correlation for final diagnosis. PMID: 31535937 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Authors: Yoo JJ, Yu SJ, Lee B, Cho EJ, Lee JH, Kim SG, Kim YJ, Kim YS, Yoon JH Abstract Background/Aims: Patients with an intermediate stage of hepatocellular carcinoma (HCC) represent a highly heterogeneous population; therefore, many models have been proposed to predict the survival of these patients. The aim of this study was to evaluate the prognostic performance of a novel subclassification for tumors classified as Barcelona Clinic Liver Cancer (BCLC) stage B using the Model to Estimate Survival in Ambulatory HCC patients (MESIAH). Methods: This analysis was based on 377 patients with HCC treated at Seoul ...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
Conclusion: Emergency SBE under general anesthesia achieves higher diagnosis and detection rates, and fewer adverse events under conscious sedation, when compared to nonemergency SBE, regardless of the route. For patients with overt bleeding, it is easier to find lesions by emergency SBE within 24 hours. PMID: 31534450 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Authors: Hotta T, Okimoto T, Hamaguchi M, Tsubata Y, Isobe T Abstract A 40-year-old Japanese man with advanced pulmonary adenocarcinoma harboring anaplastic lymphoma kinase (ALK)-rearranged was administered the selective ALK inhibitor ceritinib as a third-line treatment and continued treatment for nine months. After fourth-line treatment, we performed rechallenge with ceritinib as a fifth-line treatment. On day 54 after rechallenge, the patient developed acutely deteriorating dyspnea. Chest computed tomography showed extensive ground-glass opacities. We diagnosed him with ceritinib-induced interstitial lung disease...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion: DHA inhibited cell proliferation and induced apoptosis in human hepatocellular carcinoma cells by upregulating TNF expression via JNK/NF-κB pathways. PMID: 31534470 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Computed tomography of chemiluminescence (CTC) is one kind of volumetric tomography which can recover 3D flame structures and has found ...
Source: Optics Letters - Category: Physics Authors: Source Type: research
Abstract Uterine radial artery resistance index (URa-RI) by Doppler ultrasound may reflect the changes in the uteroplacental circulation and be associated with adverse events in early pregnancy. Recurrent pregnancy losses (RPL) are associated with thrombophilia, and anticoagulation treatment with low molecular weight heparin improves pregnancy outcome in women with RPL and thrombophilia. A retrospective cohort study was conducted in 139 pregnant women with 3 or more RPL and thrombophilia. The relationship between pregnancy outcome and dynamic changes of URa-RI was analyzed in 116 women who delivered a liveborn inf...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 19 September 2019Source: Carbohydrate PolymersAuthor(s): Isabel Romo, Lilian Abugoch, Cristian TapiaAbstractThe research aim was to study the nature of intermolecular interactions involved in the formation of soluble complexes between chenopodins (QP) and anionic/cationic polysaccharides, sodium alginate (Alg) and chitosan (CH), above the pI of QP at different protein-polysaccharide ratios; and to evaluate their structural-physicochemical properties. The interactions and properties analysed by electrical conductivity, zeta potential, hydrodynamic particle size, intrinsic and extrinsic flu...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 19 September 2019Source: Thermochimica ActaAuthor(s): Klaudia Ordon, Monika Szlachta, Piotr Szatkowski, Kinga PielichowskaAbstractNew polyurethane-based materials (PUs) have been fabricated via a two-step bulk polymerization method with starch as a crosslinker, and 1,4-butanediol as a chain extender. Hydroxyapatite (HAp) was used as a bioactive compound. The structure, morphology and thermal properties of the PUs were investigated. The chemical structure of the obtained materials was confirmed by FTIR. The SEM-EDX analysis confirmed the incorporation of starch and HAp into the PU matrix. ...
Source: Thermochimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 19 September 2019Source: PolymerAuthor(s): Khushbu, Sudhir G. Warkar, Anil KumarAbstractThe novel superabsorbent hydrogels (SAH) were fabricated by interpenetrating carboxymethyl tamarind kernel gum with sodium-acrylate. The synthesis of SAH was verified by characterization using Fourier-transform infrared spectroscopy, thermo-gravimetric analysis, scanning electron microscopy and swelling studies under various solutions. The hydrogel formed was found out to be degradable (soil burial biodegradation test). Maximum water holding capacity, bulk density, porosity and water retention capacity...
Source: Polymer - Category: Chemistry Source Type: research
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