Population Pharmacokinetic Model of Sublingual Buprenorphine in Neonatal Abstinence Syndrome

ConclusionsThis is the first study to investigate the population PK of sublingual buprenorphine in neonatal NAS. To our knowledge, this is also the first report to describe the age‐dependent changes of buprenorphine PK in this patient population. No buprenorphine dose adjustment is needed for neonates with NAS treated with buprenorphine and concurrent phenobarbital.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 1, 2015 Category: Drugs & Pharmacology Authors: Chee M. Ng, Erin Dombrowsky, Hopi Lin, Michelle E. Erlich, David E. Moody, Jeffrey S. Barrett, Walter K. Kraft Tags: Original Research Article Source Type: research