Immunogenicity to infliximab is associated with HLA-DRB1

Dear Editor, We read with great interest the manuscript by Ungar and colleagues describing the temporal evolution of antibodies to infliximab (ATI) in patients with IBD treated with infliximab (IFX).1 By prospectively following 125 patients with IBD, they showed that ATI formation is a dynamic process. Clinically relevant ATI were typically formed within the first 12 months but transient ATI, which are of little clinical significance, can be formed at any time during treatment. They furthermore demonstrated that the evolution of ATI correlates with clinical loss of response and that concomitant immunomodulator use prolonged ATI-free survival, which is in line with previous reports. Nevertheless, patient-related factors possibly influencing ATI formation weren't considered and haven't been studied extensively. We hypothesised that ATI formation may be triggered by HLA-DRB1 alleles, as was shown for immunogenicity to interferon-β therapy in multiple sclerosis.2 We retrospectively analysed 192 patients with IBD:...
Source: Gut - Category: Gastroenterology Authors: Tags: PostScript Source Type: research

Related Links:

AbstractPurpose of ReviewNeurotrophic keratopathy (NK) is a challenging ophthalmological disease. In this review, we present an updated evidence-based summary on the pathophysiology, classification, diagnosis, and how novel therapies have changed the management of NK.Recent FindingsNew specific medical and surgical modalities are emerging, such as Cenegermin (Oxervate ®, Dompé) and neurotization procedures, which are changing the paradigm of the treatment of NK. In addition, more diagnostic resources are available, such as corneal confocal microscopy in vivo, non-contact esthesiometers, and common ocular surface...
Source: Current Ophthalmology Reports - Category: Opthalmology Source Type: research
ConclusionsRelapse rates with treatment with FTY, DMF and TERI were similar. Patients treated with DMF showed less sustained disability progression for 12  weeks than FTY-treated patients. However, FTY and DMF treatment was associated with more likely EDSS regression for 12 and 24 weeks and a lower probability for treatment interruption as compared to TERI-treated patients.
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractPurposeManual measures such as corpus callosum index, normalized corpus callosum area, and width of the third ventricle are potential biomarkers for brain atrophy. In this work, we investigate their suitability to assess the neurodegenerative component of multiple sclerosis (MS) by comparing them to volumetric measures and expanded disability status scale (EDSS).MethodsFifty-eight patients with a clinically isolated syndrome, 48 MS patients treated with interferon β, and 26 treated with natalizumab underwent a brain MRI at baseline and after 1 year. Manual measures were evaluated by two observers usi...
Source: Neuroradiology - Category: Radiology Source Type: research
Nature Reviews Neurology, Published online: 03 April 2020; doi:10.1038/s41582-020-0356-0Trigeminal neuralgia linked to demyelination in multiple sclerosis
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
In this study, we tested the presence of MOG-Ab and AQP4-Ab in 57 children at first onset of acute neurological symptoms; three clinical subgroups were identified: 12 patients had acquired inflammatory demyelinating CNS syndromes, 11 had other auto immune/immune-mediated disorders of the central and peripheral nervous system and 34 had non-immune-mediated CNS disorders. MOG-Abs were found positive only in a subset of cases in the subgroup with acquired inflammatory demyelinating CNS syndromes (in 2/12 patients, both with non-MS phenotype) and in none of the patients with other autoimmune and immune-mediated disorders of th...
Source: Neurological Sciences - Category: Neurology Source Type: research
In conclusion, oculomotor impairment is a common component of disability in MS patients and should be considered when managing this type of patients. More research is still needed to know the real impact of this disease on binocular vision and accommodation. PMID: 32228341 [PubMed - as supplied by publisher]
Source: Seminars in Ophthalmology - Category: Opthalmology Tags: Semin Ophthalmol Source Type: research
Fatigue and poor sleep quality are among the most common patient-reported problems associated with multiple sclerosis (MS). Social support, on the other hand, is often found to be positively associated with quality of life in patients with neurological dis...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
Publication date: Available online 1 April 2020Source: Journal of Clinical NeuroscienceAuthor(s): Emily Cheung, Jessica Hafner, Yi-Ching Lee, Sharon Coward, Amy Lofts, John Parratt, Karl Ng
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 31 March 2020Source: Neurología (English Edition)Author(s): L.A. Rodríguez de Antonio, I. García Castañón, M.J. Aguilar-Amat Prior, I. Puertas, I. González Suárez, C. Oreja Guevara
Source: Neurologia - Category: Neurology Source Type: research
Publication date: Available online 31 March 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Razieh Amini, Sajad karampoor, Hamid Zahednasab, Hossein Keyvani, Masoud Gheiasian, Farid Azizi Jalilian
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
More News: Gastroenterology | Multiple Sclerosis | Remicade