Liver injury in acute hepatitis A is associated with decreased frequency of regulatory T cells caused by Fas-mediated apoptosis

Conclusions The size of the Treg pool was contracted during AHA, resulting from apoptosis of Tregs induced by a Fas-mediated mechanism. Decrease in Treg numbers led to reduced suppressive activity of the Treg pool and consequently resulted in severe liver injury during AHA.

http://gut.bmj.com/cgi/content/short/64/8/1303?rss=1

Source: Gut - July 9, 2015 Category: Gastroenterology Authors: Choi, Y. S., Lee, J., Lee, H. W., Chang, D.-Y., Sung, P. S., Jung, M. K., Park, J. Y., Kim, J. K., Lee, J. I., Park, H., Cheong, J. Y., Suh, K.-S., Kim, H. J., Lee, J. S., Kim, K.-A., Shin, E.-C. Tags: Hepatology Source Type: research