4 Frustrating Facts About PCOS... and What They Mean for You

Depression. Weight gain. Increased acne and hair growth. Irregular periods. Infertility. These are some of the most notable symptoms of one of the most common hormonal, metabolic and reproductive disorders found in women: polycystic ovary syndrome (PCOS). So, what is PCOS exactly? Women with PCOS have too many male hormones and not enough female hormones, which interferes with ovulation. With PCOS, the ovaries are typically enlarged and may even contain multiple small cyst-like structures (immature ovarian follicles). If left untreated, this hormone imbalance can affect everything from a woman's menstrual cycle, to her appearance, to her ability to have children, to her overall health. Unfortunately, this disorder is one of the most misunderstood, under-diagnosed and under-funded conditions affecting women's health. It's time to step up and educate ourselves. So here are four frustrating facts about PCOS and what they mean for you: 1. Between five to 10 percent of women of childbearing age in the United States, or roughly 5 million, have PCOS. That percentage makes it one of the most common hormonal endocrine disorders in women. What's more, it also makes it the most common cause of female infertility. According to Sasha Ottey, founder and executive director of PCOS Challenge, Inc., "PCOS is one of the most critical, underserved, under-diagnosed and under-funded conditions affecting women's health. We need the help of media, government agencies and funding sources to...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Source: Nano Energy - Category: Nanotechnology Source Type: research
Publication date: Available online 21 July 2018Source: Seminars in Cell &Developmental BiologyAuthor(s): Jiayun Hou, Xiangdong WangAbstractPolycomb group proteins (PcG) play important roles in the maintenance of DNA sequencing and multi-dimensional organization of genome. The main PcG complexes are consisted of Polycomb repressive complex 1 and 2, of which the diversity is dependent upon target gene sequences and functions. The present review initially explores the mechanism-based relationship and functional roles of PcG proteins in the interplay between epithelial mesenchymal transition (EMT) and chromatin dynamics in...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
CONCLUSION: Advising pregnant women about behaviours and lifestyle habits to prevent infectious diseases remains important, and information about preventive practices needs to be complete and adequate. The health care providers who participated in this study did express a clear need for information related to food safety during pregnancy and listeriosis, as supported by their lack of knowledge in some areas. If that lack is remedied, the knowledge gained could improve counselling practices. PMID: 30030057 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Publication date: Available online 21 July 2018Source: Obesity Research &Clinical PracticeAuthor(s): George L. WehbyAbstractGenetic studies of BMI have largely focused on how average BMI changes with SNPs or polygenic risk scores (PRS). We examine the effects of a BMI PRS on changes in BMI percentiles, range, and skewness using quantile regression and US nationally representative data from the Health and Retirement Survey. We find that the BMI PRS is associated with meaningfully larger weight increases at higher than lower BMI percentiles; the 90th BMI percentile increases by 4.7 units with a one SD increase in the PRS...
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
DIABETES type 2 symptoms are triggered when there are problems with blood sugar levels. This is because of problems with the hormone insulin, which affects cells ’ ability to take in sugar. It is possible to develop ‘borderline’ diabetes, or pre diabetes, before the condition. Watch out for these symptoms.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study examined the prevalence and associated factors of risky sexual behaviours among 1648 school-going adolescents using the 2012 Ghana Global School-based Student Health Survey. Our findings showed 33.5% of the participants had ever had sex 32.5% had multiple sexual partners and only 26.2% reported using condom during their last sexual intercourse. Being male, older age, anxiety, loneliness, suicidal ideation, being bullied, food insecurity (hunger), current alcohol and marijuana use were significant risk factors for being sexually experienced, multiple partners, but not condom use. Parental knowledge of activity wa...
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In this study, we found that overexpression of nicotinamide nucleotide transhydrogenase (NNT) was associated with shorter overall and disease free survival in gastric cancer. The NNT is considered a key antioxidative enzyme based on its ability to regenerate NADPH from NADH. Knockdown of NNT caused significantly NADPH reduction, induced high levels of ROS and significant cell apoptosis under oxidative stress conditions such as glucose deprival and anoikis. In vivo experiments showed that NNT promoted tumor growth, lung metastasis and peritoneal dissemination of gastric cancer. Moreover, intratumoral injection of NNT siRNA ...
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Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Rui Xin, Xuhong Sun, Ziying Wang, Wendan Yuan, Weidong Jiang, Lin Wang, Yanxiao Xiang, Hongqin Zhang, Xiaoyan Li, Yun Hou, Wangnan Sun, Pengchao DuAbstractAimsIn this animal study, we tried to test the hypothesis that apocynin could play an anti-inflammation role by inhibiting NLRP3/X-linked inhibitor of apoptosis protein (XIAP) signalling and have an effect on antifibrosis in rats with diabetic nephropathy.Main methodsDiabetic nephropathy rats were induced by tail-vein injection of streptozotocin at 60 mg/kg body weight in sodiu...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusion: Overall, the results of this study suggested the potential beneficial effects of the extract mixture for use as complementary medicine alongside conventional treatment of metformin. The extract mixture contained many highly potent compounds for treating T2DM and preventing short- and long-term risk complications of diabetes.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
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