Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites

In conclusion, GSH still remains the gold trapping standard for reactive metabolites. However, targeted d-peptides could provide additional information about protein binding potential of electrophilic agents, but their clinical significance needs to be clarified using a wider spectrum of chemicals together with other safety estimates.
Source: Toxicology Reports - Category: Toxicology Source Type: research