Researchers identify gene responsible for some cases of male infertility

(Wiley) In about one-sixth of the cases of male infertility, men do not make any measurable levels of sperm, a condition called azoospermia. New research led by University of Pennsylvania scientists suggests that mutations in an X chromosome gene called TEX11 are responsible for about 1 percent of azoospermia cases.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Abstract BACKGROUND: Cryptorchidism is one of the most common causes of non-obstructive azoospermia (NOA) leading to male infertility. Despite various medical approaches been utilised, many patients still suffer from infertility. MicroRNAs (miRNAs) play vital roles in the progress of spermatogenesis; however, little is known about the miRNA expression profile in the testes. Therefore, the miRNA profile was assessed in the testis of post-cryptorchidopexy patients. METHODS: Three post-cryptorchidopexy testicular tissue samples from patients aged 23, 26 and 28 years old and three testis tissues from patient...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Cryptorchidism is one of the most common causes of non-obstructive azoospermia (NOA) leading to male infertility. Despite various medical approaches been utilised, many patients still suffer from infertility. ...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
In this study, whole-exome sequencing (WES) was applied to two Estonian brothers diagnosed with NOA and Sertoli cell-only syndrome (SCOS). Compound heterozygous loss-of-function (LoF) variants in FANCM (Fanconi anemia complementation group M) were detected as the most likely cause for their condition.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
ConclusionThe results of our study suggest that positive association of rs551373 SNP probably reveals an important role in azoospermia male infertility. Further studies with larger sample size are required to support our findings. Investigation of association of this SNP with other types of non-obstructive male infertility is also suggested.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
ConclusionSemen quality is generally lower in male infertility patients from the MENA region compared to non-MENA regions.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionThe incidence of chromosomal abnormalities in Qatar as a cause of severe male infertility is within a similar range as their prevalence internationally.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionsImpaired semen parameters alone cannot be used to predict fertility as these men still have a chance of being fertile, except when a man has azoospermia, necrospermia or globozoospermia.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionsMale infertility is a condition that is genetically heterogeneous, and therefore remarkably amenable to study by NGS. Although some headway has been made, given the high incidence of this condition despite its detrimental effect on reproductive fitness, there is significant potential for further discoveries.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
B. H. Han, S. B. Park, J. T. Seo and Y. K. Chun
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Urological Survey Source Type: research
ConclusionThe results of our study suggest that positive association of rs551373 SNP probably reveals an important role in azoospermia male infertility. Further studies with larger sample size are required to support our findings. Investigation of association of this SNP with other types of non-obstructive male infertility is also suggested.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
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