Fred Hutch researcher gets $12.9M for 'bubble boy,' sickle-cell anemia work

Dr. Rainer Storb wants to make transplants safer and more widely available for patients who already suffer from immune diseases, such as "bubble-boy" disease. Now, Storb will have $12.9 million to work on that research, thanks to a grant from the National Heart, Lung, and Blood Institute. “Current approaches at cell and gene therapy for lethal noncancerous diseases of the blood and immune systems have inherent toxicities that may affect patients for the rest of their lives,” Storb said in a…
Source: Health Care:Hospitals headlines - Category: Hospital Management Authors: Source Type: news

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[Guardian] In Nigeria, over 150,000 children are born annually with symptomatic sickle cell anaemia, 1-in-4 people are healthy carriers of the disease.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Source Type: research
In this report, we emphasize the peculiarities of perioperative care in patients with sickle cell anemia.
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusions It is hoped that protocols that deliver almost universally applicable low-cost tests, without compromising diagnostic accuracy, will improve patient access to preimplantation genetic testing, especially in less affluent parts of the world.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Conclusions Severe anemia appears to be a risk factor for preeclampsia/eclampsia, while sickle cell disease may be a risk factor for gestational hypertension among women seeking hospital care in developing countries.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Conclusion Indirect causes were present in less than 10% of the overall cases, but they represented over 40% of maternal deaths in the current study. Indirect causes of maternal morbidity/mortality were also responsible for an increased risk of higher severity, and they were associated with worse maternal and perinatal outcomes. In middle-income countries there is a mix of indirect causes of maternal morbidity/ mortality that points to some advances in the scale of obstetric transition, but also reveals the fragility of health systems.Resumo Objetivo O objetivo deste estudo é avaliar a importância das causas i...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
In this report, we emphasize the peculiarities of perioperative care in patients with sickle cell anemia.
Source: Brazilian Journal of Cardiovascular Surgery - Category: Cardiology Source Type: research
Abstract In sickle cell anemia, polymerization of hemoglobin in its deoxy state leads to the formation of insoluble fibres that result in sickling of red blood cells. Stereo-specific binding of isopropyl group of βVal6, the mutated amino acid residue of a tetrameric sickle hemoglobin molecule (HbS), with hydrophobic groove of another HbS tetramer initiates the polymerization. Glutathionylation of βCys93 in HbS was reported to inhibit the polymerization. However, the mechanism of inhibition in polymerization is unknown to date. In our study, the molecular insights of inhibition in polymerization were inve...
Source: The Biochemical Journal - Category: Biochemistry Authors: Tags: Biochem J Source Type: research
Public Health Nursing, EarlyView.
Source: Public Health Nursing - Category: Nursing Authors: Source Type: research
DISCUSSION: SNHL is a common complication in SCA; furthermore, this study identified a significant association between ED and SNHL. Damage to the vascular endothelium because of inflammation in SCA reduced blood flow in the inner ear. Thus, this circulatory disorder culminates in vaso-occlusive process and induces auditory disorders, such as SNHL. PMID: 29806800 [PubMed - as supplied by publisher]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
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