A key role for CEP63 in brain development and fertility discovered

(Institute for Research in Biomedicine (IRB Barcelona)) The protein CEP63 is crucial for the correct division of brain stem cells. In its absence, mice reproduce Seckel syndrome. The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.Also, CEP63-depleted male mice are infertile. The relationship between this protein and sperm production is revealed for the first time.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Authors: Yu J, Chen B, Zheng B, Qiao C, Chen X, Yan Y, Luan X, Xie B, Liu J, Shen C, He Z, Hu X, Liu M, Li H, Shao Q, Fang J Abstract Germ cell maturation is essential for spermatogenesis and testis homeostasis. ATP synthase serves significant roles in energy storage in germ cell survival and is catalyzed by alterations in the mitochondrial membrane proton concentration. The intrinsic cellular mechanisms governing stem cell maturation remain largely unknown. In the present study, in vivo RNA interference (RNAi) screening of major ATP synthase subunits was performed, and the function of ATP synthase for male fe...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth. But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized fertility Research Source Type: news
Contributors : Abhishek Sohni ; Kun Tan ; Hye-Won Song ; Dana Burow ; Miles F WilkinsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSpermatogenesis has been well studied in rodents and invertebrates, but remains poorly understood in humans. As a step towards illuminating human spermatogenesis, we used single-cell RNA-sequencing (scRNAseq) analysis to analyze neonatal and adult human testes. Clustering analysis of neonatal testes revealed 3 germ subsets, including cells with characteristics of primordial germ cells (PGCs), and more differentiated cells with gene expression profiles ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Abstract Overcoming infertility with assisted reproduction requires high-quality eggs and sperm. For those young women who no longer make functional eggs, the hope of conceiving a biological child just got one step closer with a recent publication in Science from Yamashiro et al. (2018). PMID: 30526878 [PubMed - in process]
Source: Cell Stem Cell - Category: Stem Cells Authors: Tags: Cell Stem Cell Source Type: research
ntsIntroductionMyelodysplastic syndrome (MDS) is clinically and biologically heterogeneous. Although the pathobiology of MDS is complex and not fully understood, the development of MDS involves a series of genetic changes, which influence hematopoietic growth and differentiation, resulting in the accumulation of abnormal cells and the impairment of normal hematopoiesis. Recently, Lindsley et al. reported the difference in the mutation of MDS genes in adolescent and young adult (AYA) patients and elder patients. These results suggested that MDS in AYA patients was biologically different from MDS in elderly patients. In addi...
Source: Blood - Category: Hematology Authors: Tags: 732. Clinical Allogeneic Transplantation: Results: Poster II Source Type: research
IntroductionBone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders and has demonstrated impressive outcomes in autoimmune diseases. Prior to BMT, patients are prepared with high-dose chemotherapy alone or with total body irradiation, and both are associated with early and late morbidities, such as infertility, secondary malignancies and organ toxicity; and substantial risk of mortality. This greatly limits the use of BMT in malignant and non-malignant conditions. To address these issues, we are developing antibody drug conjugates (ADCs) targeting hematopoietic stem ...
Source: Blood - Category: Hematology Authors: Tags: 701. Experimental Transplantation: Basic Biology, Pre-Clinical Models: Poster III Source Type: research
Conclusions: Anti-CD117-AM exhibited potent elimination of NHP HSCs and progenitors in vivo. The potency of short half-life anti-CD117-AM was comparable, providing a model for target cell depletion and rapid clearance prior to BMT. Both ADCs were well tolerated at the efficacious doses. This strategy preserves the adaptive immune system with delayed onset of neutrophil nadir (18 days), potentially shortening the period of neutropenia. Targeted depletion of hematopoietic cell subtypes with limited off-target effects could provide a significant improvement in standard-of-care approaches to patient preparation prior to HSC tr...
Source: Blood - Category: Hematology Authors: Tags: 701. Experimental Transplantation: Basic Biology, Pre-Clinical Models: Poster II Source Type: research
Conclusion: This study confirms a low pregnancy rate in survivors of childhood HSCT. Natural conception was possible when patients are conditioned without TBI. After TBI, pregnancy assisted fertilization techniques may increase pregnancy rate. The number of live births and complications indicate the need to advise survivors of childhood HSCT about the potential risks and outcome of pregnancy and advise them appropiately.DisclosuresBader: Cellgene: Consultancy; Neovii: Research Funding; Medac: Patents &Royalties, Research Funding; Riemser: Research Funding; Novartis: Consultancy, Speakers Bureau.
Source: Blood - Category: Hematology Authors: Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster II Source Type: research
Background.Infertility is common after HCT predominantly as a result of the chemoradiotherapy used in conditioning. Patients are increasingly encouraged to store gametes, tissue or embryos before transplant for use after their potentially sterilising treatment. Furthermore, some patients do retain or recover fertility and conceive naturally.Methods:We sent questionnaires to 602 EBMT centers requesting retrospective details of number of pregnancies following either allogeneic or autologous HCT, use of artificial reproductive techniques (ART) and pregnancy outcome for all patients treated between 1995-2015.Results:47 centers...
Source: Blood - Category: Hematology Authors: Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster I Source Type: research
Publication date: January 2019Source: Biomedicine &Pharmacotherapy, Volume 109Author(s): G.D. Sagaradze, N.A. Basalova, V.I. Kirpatovsky, D.A. Ohobotov, O.A. Grigorieva, V.Yu. Balabanyan, A.A. Kamalov, A.Yu. EfimenkoAbstractMale infertility represents a severe social and medical challenge. In recent years the progress in regenerative medicine promoted the development of novel options to overcome this medical condition. We are elaborating a promising approach to restore spermatogenesis using mesenchymal stromal cell (MSC) secretome components as a novel class of cell-free cell therapy medicinal products for regenerative...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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