Association between genetic condition, hormonal factors, and risk of endometrial cancer

For women with Lynch syndrome, an association was found between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use, according to a study. Lynch syndrome is a genetic condition that increases the risk for various cancers.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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In this study we modified the capture –recapture method from ecology to estimate the number of families in central Ohio with Lynch syndrome (LS). We screened 1566 colorectal cancer cases and 545 endometrial cancer cases in central Ohio from 1999 to 2005 and identified 58 with LS. We screened an additional 3346 colorectal and 342 endom etrial cancer cases from 2013 to 2016 and identified 149 with LS. We found 12 LS mutations shared between families observed in the first and second studies. We identified three individuals between studies who were closely related and eight who were more distantly related. We used identi...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
We report here a 16-year-old patient who presented initially with symptoms characteristic of appendicitis. Following a CT scan suggesting perforated appendicitis, the patient was treated with intravenous antibiotics with a scheduled interval appendectomy three months later. Pathology reports from the interval appendectomy showed that the specimen contained a well-to-moderately differentiated adenocarcinoma. The patient then underwent robot assisted right hemicolectomy as definitive management, which demonstrated that the tumor originated in the cecum with invasion into the submucosa and focally infiltrating the muscularis ...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Introduction: Gastric cancer (GC) risk in Lynch Syndrome (LS) is up to 13% instead of less than 1% in general population. LS is an autosomal dominant disorder caused by germ-line mutations in one of the mismatch repair (MMR) genes (MSH2, MLH1, MSH6, PMS2) or EpCAM gene determining mainly risk of colorectal and endometrial cancer and a lower risk of small bowel, urothelial and gastric cancer. GCs in this setting are usually intestinal type and show microsatellite instability (MSI-H) and loss of MMR protein expression. There are not clear guidelines for surveillance because the histopathologic transformation pathway is unkno...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Ovarian cancer in women with LS has a wide age-range of onset, is usually diagnosed at an early stage with predominantly endometrioid type histology and a good overall survival. The early stage at diagnosis could not be attributed to annual gynecological surveillance. PMID: 29880284 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
CHICAGO (Reuters) - Lynch syndrome, a rare hereditary disease typically associated with an increased risk of colorectal and endometrial cancers, appears to be linked with several additional types of cancer than previously thought, U.S. researchers said on Saturday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Lynch syndrome is an autosomal dominant inherited disease caused by germline mutations in mismatch repair genes. Analysis for microsatellite instability (MSI) and immunohistochemistry (IHC) of protein expressi...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
Cancer, EarlyView.
Source: Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractLynch syndrome (LS) is one of the most common genetic cancer syndromes, occurring at a rate of 1 per 250 –1000 in the general population. This autosomal dominant disease is caused by a germline variant in one of the four mismatch repair genes,MSH2, MLH1, MSH6, PMS2, or theEPCAM gene. LS develops at early ages in colorectal cancer (CRC), endometrial cancer, and various other associated tumors. Accurate diagnosis of LS and utilization of various risk-reduction strategies such as surveillance, prophylactic surgery, and chemoprevention could improve clinical outcomes. The efficacy of surveillance has only been pr...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: AGA Abstracts Source Type: research
The Cancer Genome Atlas (TGCA) studies have defined the molecular genetic landscape of endometrial cancer and highlighted the molecular genetic diversity of both endometrioid and non-endometroid cancers [1]. The TCGA established four distinct endometrial cancer subclasses based on the extent of mutational load and somatic copy number alterations. The first molecular subclass of ultramutated cancers is characterised by mutations in the exonuclease domain of DNA polymerase epsilon (POLE), which has evoked substantial interest and specific research, as these cancers have an exceptionally good prognosis with very few recurrenc...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
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