Effects of Arsenite Exposure during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Disease in Male Mice

Conclusions: In utero and continuous early life exposure to As (III) disrupted normal metabolism and elevated the risk for fatty liver disease in mice maintained on a high fat diet. Our findings suggest that individuals exposed to As (III) during key developmental periods, and who remain exposed to As (III) on the background of a Western diet, may be at increased risk of metabolic disease later in life. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Ditzel EJ, Nguyen T, Parker P, Camenisch TD. Effects of Arsenite Exposure during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Disease in Male Mice. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1409501. Received: 18 November 2014 Accepted: 2 July 2015 Advance Publication: 7 July 2015 EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehp50...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research